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Nikolaev V, Naydenova E, Kerimova M, Dimov S, Ivanov E: Rat liver plasma membrane damage in hexachlorobenzene intoxication and its potentiation by ethanol. Toxicol Lett. 1986 Sep;32(3):269-73.
Chronic feeding of male Wistar rats with food containing hexachlorobenzene (HCB) at 17.5 mmol/kg induced elevation of serum amino-transferases and bilirubin content, increase of microsomal cytochrome P-450 concentration, and decrease of 5'-nucleotidase, K+,Na+- and Mg2+-adenosine triphosphatase activities in liver plasma membrane preparations. These changes were potentiated by ethanol consumption suggesting a possible role of liver plasma membrane damage in the pathogenesis of HCB intoxication. |
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