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Ohyama T, Takahashi T, Ogawa H: Effects of dichlorodiphenyltrichloroethane and its analogues on rat liver mitochondria. Biochem Pharmacol. 1982 Feb 1;31(3):397-404.
The effects of dichlorodiphenyltrichloroethane (DDT) and sixteen analogues on respiration, swelling and latent ATPase of rat liver mitochondria were examined systematically. The compounds tested could be divided into four groups: DDT-type, DDE-type, kelthane-type and others by substituent groups on the ethane bridge of bis (p-chlorophenyl) ethane. Most compounds tested were shown to inhibit State 3 respiration. A linear relation was observed between the logarithms of the concentrations giving half-inhibition of State 3 respiration and the logarithms of the partition coefficients of the tested compounds. Four compounds of the kelthane type and chlorobenzilate stimulated State 4 respiration to the level of dinitrophenol-stimulated respiration. The compounds that have a hydroxy group on the ethane bridge-rapidly induced mitochondrial swelling, but DDT-type and DDE-type compounds induced swelling when the suspension contained 0.15 M KCl and 5 mM Tris-HCl. Latent ATPase of mitochondria was stimulated to different maximum levels by each of the tested compounds except DDA. The oligomycin-sensitive ATPase of submitochondria was inhibited by a series of kelthane-type compounds. |
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