| 2160139 |
Landers JP, Birse LM, Nakai JS, Winhall MJ, Bunce NJ: Chemically induced hepatic cytosol from the Sprague-Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah receptor. Toxicol Lett. 1990 May;51(3):295-302.
A series of exogenous chemicals was used as potential inducers for the hepatic Ah receptor in the Sprague-Dawley rat. 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,2',4,4',5,5'-hexachlorobiphenyl and phenobarbital all induced an elevated level of 3H-2,3,7,8-tetrachlorodibenzo-p-dioxin specific binding, while 3,3',4,4'-tetrachloroazobenzene and trans-3,3',4,4'-tetrachlorostilbene caused a depression. Mixtures of these chemicals caused additive effects. Elevated levels of specific binding appeared to be heterologous, comprising a binding species having the normal high stability of the Ah receptor in its liganded form, and another less stable substance having a half-life of approximately 2 h at 37 degrees C. |
3(0,0,0,3) |