| 19831022 |
Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP: Anti-HIV diterpenes from Coleus forskohlii. Nat Prod Commun. 2009 Sep;4(9):1173-5.
Various extracts of the aerial parts of Coleus forskohlii (Labiatae) were prepared and evaluated at their non cytotoxic concentration against HIV-1 NL4-3. Chloroform, ethyl acetate and n-butanol extracts showed 45.6, 66.5 and 37.7% inhibition of HIV, respectively in CEM-GFP cells infected with HIV-1 (NL4-3) at 5 microg/mL. Four diterpenes, 1-deoxyforskolin, 1,9-dideoxyforskolin, forskolin and isoforskolin were isolated from the chloroform extract and tested against the virus. Six semi-synthetic derivatives of forskolin have been prepared to study SAR. 1-Deoxyforskolin and forskolin were found to be active against HIV (NL4-3). This is first report of anti HIV activity of this plant and its isolated constituents. |
83(1,1,1,3) |