| 11308331 |
Pahari AK, Majumdar S, Mandal TK, Chakraborty AK, Bhattacharyya A, Chowdhury A: Toxico-kinetics, recovery, and metabolism of napropamide in goats following a single high-dose oral administration. J Agric Food Chem. 2001 Apr;49(4):1817-24.
Toxicokinetic behavior, recovery and metabolism of napropamide (a pre-emergent herbicide) and its effect on Cytochrome P (450) of liver microsomal pellet were studied following a single high-dose oral administration of 2.5 g kg (-1) and continuous (7 days) oral administration of 500 mg kg (-1) in black Bengal goat. Napropamide was detected in blood at 15 min and the maximum quantity was recovered at 3 h after administration. The absorption rate constant (Ka) value was low indicating poor absorption from the gastrointestinal tract. High elimination half-life (t (1/2) beta) and low body clearance (Cl (B)) values coupled with higher transfer of compound from tissue to central compartment (K (21)) suggest that napropamide persisted in the blood for a long time, i.e., after 72 h of oral administration. The recovery percentage of napropamide, including metabolites, from goats varied from 75.94 to 80.08 and excretion of the parent compound through feces varied from 18.86 to 21.59%, indicating that a major portion of the orally administered napropamide was absorbed from the gastrointestinal tract of goat. Napropamide significantly increased the Cytochrome P (450) content of liver microsomal pellet. The recovery of metabolites from feces, urine, and tissues ranged from 4.2--6.2, 40.81--49.42, and 2.7--11.6%, respectively, during a 4--7 day period. The material balance of napropamide (including metabolites) following a single high-dose oral administration at 2.5 g kg (-1) during 4--7 days after dosing was found to be in the range of 75--80%. |
37(0,1,2,2) |