| ID | 21 |
|---|---|
| Name | chloride channel (protein family or complex) |
| Synonyms | chloride channel |
| ID | 182 |
|---|---|
| Name | endosulfan |
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 9147380 | Huang J, Casida JE: Role of cerebellar granule cell-specific GABAA receptor subtype in the differential sensitivity of [3H] ethynylbicycloorthobenzoate binding to mimetics. Neurosci Lett. 1997 Apr 4;225(2):85-8. Binding of [3H] ethynylbicycloorthobenzoate ([3H] EBOB) to the type A (GABAA) receptor of cultured cerebellar granule neurons is inhibited by muscimol and 3-aminopropanesulfonic acid with IC50 values of 69-250 nM. Sensitivity to these mimetics is lower by 3-4-fold for cerebellum and 10-20-fold for cerebral cortex, midbrain, and pons and medulla, a differential sensitivity by brain region and cell type consistent with earlier findings using tert-[35S] butylbicyclophosphorothionate and In contrast, the inhibitory potencies of two chloride channel blockers, alpha-endosulfan and picrotoxinin, do not differ in these assays. The hypothesis that this pharmacological profile is conferred by the alpha 6 subunit specific to cerebellar granule cells is supported by the finding that forskolin (which downregulates the alpha 6 subunit) but not the inactive dideoxyforskolin markedly decreases the sensitivity of [3H] EBOB binding to without affecting inhibition by alpha-endosulfan. |
0(0,0,0,0) |