calreticulin

General Information (Source: NCBI Gene,UniProt)

Text mining Term calreticulin
UniProt ID CALX_HELTU
Name Calnexin homolog
Gene Names
Taxonomy Helianthus tuberosus

General annotation

Function Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
Subcellular location Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity).

Gene Ontology

GO:0016021 integral to membrane CC
GO:0005509 calcium ion binding MF
GO:0051082 unfolded protein binding MF
GO:0005529 sugar binding MF
GO:0006457 protein folding BP
GO:0005789 endoplasmic reticulum membrane CC

Sequence

>gi|11131766|sp|Q39994.1|CALX_HELTU RecName: Full=Calnexin homolog; Flags: Precursor
MELSRRKMCCYIQFCCFVLIGCFISQICASSDAIFYESFDESFEGSWIVSEKEDYPGEWKHSKSEGHDDY
GLLVSDKARKYAIVKELEKPVELKDGTIVLQYEVRLQNGLECGGAYLKYLRPQDAGWTAKGFDNESPYSI
MFGPDKCGATNKVHFILKHKNPKSGDYVEHHLKFPPSVPSDKLTHVYTAVIKPDNELVILIDGEEKKKAN
FLSSEDFEPALIPTKTIPDPDDKKPEDWDERAKIPDPEATKPDDWDEDAPMEILDEEAEKPEGWLDDEPE
EIDDPEAVKPEDWDDEEDGEWEAPQIENPKCESAPGCGEWRRPLKRNPAYKGKWHAPLIDNPAYKGIWKP
REIPNPDYFELEKPNFEPIAAIGIEDLDQQDGILFDNILIASDEKTAAKSGILLGSRSLRWKKRNRRLKK
NQPLLDGLKGIQKAVFDVLYKIADLPFLGDHKVKVLELIEKAETQPNITIGVIVSIIVVIFSILLKLLFG
GKKAAPKVNVVPKKKEEPEASNTAEVREGEEEKTEGEVAAAPRRRPRRDT

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00262