vesicular GABA transporter

General Information (Source: NCBI Gene,UniProt)

Text mining Term vesicular GABA transporter
UniProt ID S6A12_RAT
Name Solute carrier family 6 member 12
Sodium- and chloride-dependent betaine transporter
Na(+)/Cl(-) betaine/GABA transporter
Gene Names Slc6a12
Taxonomy Rattus norvegicus

General annotation

Function Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity).
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0010033 response to organic substance BP
GO:0071474 cellular hyperosmotic response BP
GO:0005328 neurotransmitter MF
GO:0009992 cellular water homeostasis BP
GO:0005332 gamma-aminobutyric acid MF
GO:0005887 integral to plasma membrane CC

Sequence

>gi|8394200|ref|NP_059031.1| sodium- and chloride-dependent betaine transporter [Rattus norvegicus]
MSSGAWEERVSLSSMDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGL
GNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIE
SYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRV
LGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQG
IVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFV
VFSILGFMAQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTA
SMDMFPQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVY
GADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGWLLAFSS
MACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSPVKQELIAWEKETHL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000018821
UniGene Rn.11352
PDB
RefSeq NP_059031.1
Pfam PF00209