brain derived neurotrophic factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term brain derived neurotrophic factor
UniProt ID BDNF_RAT
Name Brain-derived neurotrophic factor
BDNF
Gene Names Bdnf
Taxonomy Rattus norvegicus

General annotation

Function During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0008083 growth factor activity MF
GO:0048172 regulation of short-term neuronal synaptic plasticity BP
GO:0050890 cognition BP
GO:0060079 regulation of excitatory postsynaptic membrane potential BP
GO:0002544 chronic inflammatory response BP
GO:0005169 neurotrophin TRKB receptor binding MF
GO:0055093 response to hyperoxia BP
GO:0009725 response to hormone stimulus BP
GO:0048170 positive regulation of long-term neuronal synaptic plasticity BP
GO:0072347 response to anesthetic BP
GO:0014076 response to fluoxetine BP
GO:0030182 neuron differentiation BP
GO:0005576 extracellular region CC
GO:0001666 response to hypoxia BP
GO:0042493 response to drug BP
GO:0008021 synaptic vesicle CC
GO:0045843 negative regulation of striated muscle tissue development BP
GO:0006120 mitochondrial electron transport, NADH to ubiquinone BP
GO:0033189 response to vitamin A BP

Sequence

>gi|6978569|ref|NP_036645.1| brain-derived neurotrophic factor precursor [Rattus norvegicus]
MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIE
ELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGEL
SVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQC
RTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR

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Database Cross Reference

Ensembl Gene
UniGene Rn.11266
PDB
RefSeq NP_036645.1
Pfam PF00243