p38

General Information (Source: NCBI Gene,UniProt)

Text mining Term p38
UniProt ID CRK_MOUSE
Name Proto-oncogene c-Crk
p38
Adapter molecule crk
Gene Names Crk
Synonyms:Crko
Taxonomy Mus musculus

General annotation

Function The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Subcellular location Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma membrane upon cell adhesion (By similarity).

Gene Ontology

GO:0032956 regulation of actin cytoskeleton organization BP
GO:0032319 regulation of Rho GTPase activity BP
GO:0005070 SH3/SH2 adaptor activity MF
GO:0045309 protein phosphorylated amino acid binding MF
GO:0046875 ephrin receptor binding MF
GO:0048013 ephrin receptor signaling pathway BP
GO:0005886 plasma membrane CC

Sequence

>gi|31559995|ref|NP_598417.2| adapter molecule crk [Mus musculus]
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPP
VPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSRQGSGVILRQEEAEYVRAL
FDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHP
QPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECN
GKRGHFPFTHVRLLDQQNPDEDFS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000017920
UniGene Mm.280125
PDB 1M3A
1CKB
1M3B
2GGR
1B07
1M3C
1JU5
1CKA
1M30
RefSeq NP_598417.2
Pfam PF00017
PF00018
PF07653