demethylase

General Information (Source: NCBI Gene,UniProt)

Text mining Term demethylase
UniProt ID NO66_DROSI
Name Lysine-specific demethylase NO66
Nucleolar protein 66
Gene Names
Taxonomy Drosophila simulans

General annotation

Function Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
Subcellular location Nucleus (By similarity).

Gene Ontology

GO:0045892 negative regulation of transcription, DNA-dependent BP
GO:0006351 transcription, DNA-dependent BP
GO:0032453 histone demethylase activity (H3-K4 specific) MF
GO:0051864 histone demethylase activity (H3-K36 specific) MF
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen MF
GO:0005506 iron ion binding MF
GO:0005634 nucleus CC

Sequence

>gi|284433507|sp|B4R4H1.1|NO66_DROSI RecName: Full=Lysine-specific demethylase NO66; AltName: Full=Nucleolar protein 66
MEKVTNSAAAKPQGNNKKQESAYNGTAKDKKKPNLDIETTDSDLLSDIHLDGTKEQKVQTLFSKVFEDTG
PSTAKTADRKRRLQAEADANNNDTEKASKLAKTSVATTDMDLRVTRKQHTFYMKVQALLAEHAEKESTKK
ASKMAKISEADLILFMTQKEIEYYMKVKALIAKCAEEGSKLLDNWTSSKDIAKTADHERRLQAEADAKNN
DTKKAGQSAKESVATTDMQLNVIKEQMEHCKKVQALLANESKGAEKESKVLDYSTGPSTSSKEAAAAKTA
DHERRLLAEADVNNNDTEKAGQSAMESVATQGASATERKQSFSLGLEHTSPIQVNGAALACPLVRKSLPP
GEANSCPPPPKRDPAAVKSSVKIIKVKAPEEGNNNNDEKEMSTETSETHKTDSVEEGRRVVKWIIFPIKP
NFFFKYFWEQTACLVQRTNPKYFQSLISFKMLDEILIRHHLDFTVNLDVTTYKNGKRETLNPEGRALPPA
VWGFYSEGCSIRLLNPSAYLTRLREVCTVLQEFFHCKVEANMYLTPPNSQGFAPHYDDIEAFVIQVEGRK
RWLLYEPPKEADHLARISSGNYDQEQLGKPIIDEVLSAGDVLYFPRGTVHQAITEEQQHSLHITLSVYQQ
QAYANLLETLMPMVLKKAVDRSVALRRGLPLHTFQVLGNAYKANDCGSRQLLVENVQKLVTKYLIPSEDD
IDEAVDQMAKKFQHEALPPIVLPSEEVRTVHGARSGADEQGNCVCDYKFNEKTSVRLLRANILRLVTEPD
GSVRIYHHADNGLDYCKYEPYFMEILPEEAKAVELLISAYPYYLTIDQLPLKSSARKVEVATALWEHGLL
MTEKPFK

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dsi.10917
PDB
RefSeq XP_002106114.1
Pfam PF08007