acetylcholine receptors (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term acetylcholine receptors (protein family or complex)
UniProt ID ACH2_DROME
Name Acetylcholine receptor subunit alpha-like 2
Gene Names
Taxonomy Drosophila melanogaster

General annotation

Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0030054 cell junction CC
GO:0004872 receptor activity MF
GO:0045211 postsynaptic membrane CC
GO:0004889 acetylcholine-activated cation-selective channel activity MF
GO:0005886 plasma membrane CC
GO:0016021 integral to membrane CC

Sequence

>gi|113054|sp|P17644.1|ACH2_DROME RecName: Full=Acetylcholine receptor subunit alpha-like 2; Flags: Precursor
MAPGCCTTRPRPIALLAHIWRHCKPLCLLLVLLLLCETVQANPDAKRLYDDLLSNYNRLIRPVSNNTDTV
LVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGE
YVVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDN
KVEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSV
LVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHY
RKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPD
SLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSVLSGLDDSLSDVAARKKYPFEL
EKAIHNVMFIQHHMQRQDEFNAEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSLYDDTKAIDVQ
LSDVAKQIYNLTEKKN

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Database Cross Reference

Ensembl Gene
UniGene Dm.2363
PDB
RefSeq NP_524482.1
NP_733001.1
Pfam PF02932
PF02931