P glycoprotein

General Information (Source: NCBI Gene,UniProt)

Text mining Term P glycoprotein
UniProt ID MDR65_DROME
Name P-glycoprotein 65
Multidrug resistance protein homolog 65
Gene Names Mdr65
Taxonomy Drosophila melanogaster

General annotation

Function
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0008559 xenobiotic-transporting ATPase activity MF
GO:0016021 integral to membrane CC
GO:0043190 ATP-binding cassette (ABC) transporter complex CC
GO:0005524 ATP binding MF
GO:0031427 response to methotrexate BP
GO:0060856 establishment of blood-brain barrier BP

Sequence

>gi|157875|gb|AAA28680.1| P-glycoprotein [Drosophila melanogaster]
MERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYS
EFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVD
VFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITV
AISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEV
QRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGI
IVGADNIARTAPFLESFASARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEV
IVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEP
VLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQ
NPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA
LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNLEKGQKNSVQFEEPIIKALIKDT
NAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALR
RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG
EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVI
EEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYG
GVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLA
KQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHI
DHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGY
DTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLS
TVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQKDH

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene
UniGene Dm.4740
PDB
RefSeq NP_476831.1
Pfam PF00005
PF00664