GTP binding proteins

General Information (Source: NCBI Gene,UniProt)

Text mining Term GTP binding proteins
UniProt ID LSG1_DROME
Name Large subunit GTPase 1 homolog
Nucleostemin-3
Gene Names ns3
Taxonomy Drosophila melanogaster

General annotation

Function GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exert global growth control.
Subcellular location Cytoplasm. Note=Punctate distribution.

Gene Ontology

GO:0040008 regulation of growth BP
GO:0015031 protein transport BP
GO:0005525 GTP binding MF
GO:0005783 endoplasmic reticulum CC
GO:0016787 hydrolase activity MF
GO:0015030 Cajal body CC
GO:0007275 multicellular organismal development BP
GO:0046626 regulation of insulin receptor signaling pathway BP
GO:0051168 nuclear export BP

Sequence

>gi|74949081|sp|Q9W590.1|LSG1_DROME RecName: Full=Large subunit GTPase 1 homolog; AltName: Full=Nucleostemin-3
MGKKNKGGAPNLGRQLIKDRFGHTQRRKVDNDTMLHTTELQDGYDWGRLNLSSVTEESSFQAFLRTAELA
GTEFQAEKLNITFVNPKQRVGLLSKTQEQRMHQKHDEHRDQLKIPRRPKWTKETSAEELVRAENEAFLDW
RRDLALLQEDEEILMTPYEKNLEFWRQLWRVVERSDVVVQIVDARNPLLFRSADLERYVKEVEPSKMNMI
LVNKSDLLTEEQRRHWAEYFDSEGIRTAFYSATLVEEELKREAEECLDSFPEVQQLRRAVEEIKQSLDSV
EDALNVIEQKYKTIPETQNDELPRLPGDKNSPRLLSRLELIEFLRNIYTGPRHTEQHVTVGMVGYPNVGK
SSTINSLMTVKKVSVSATPGKTKRFQTLFLDKDILLCDCPGLVMPSFVLTKADMLLNGILPIDQMRDHVP
AVNLLCERIPRHVLEDKYGIVIAKPLEGEDMERPPHSEELLLAYGYNRGFMTSNGQPDQARSARYVLKDY
VNGRLLYAMSPPSVPQTEYHTFPERQRRVIEESQLPGQQQRAMRINKSTSKELDNQFFSDKPTHAHVKGR
TNFPNVRLANDGSLVAGNDPAAKPWRHVKKERREKLRKKFSHLDEH

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Database Cross Reference

Ensembl Gene
UniGene Dm.4650
PDB
RefSeq NP_569915.1
Pfam PF01926