| 19534555 |
Vanek V, Budesinsky M, Kabeleova P, Sanda M, Kozisek M, Hanclova I, Mladkova J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jiracek J: Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem. 2009 Jun 25;52(12):3652-65.
The inhibitors were designed to mimic the hypothetical transition state of BHMT substrates and consisted of analogues with NH, N (CH (3)), or N (CH (3))(2) groups separated from the homocysteine sulfur atom by a methylene, ethylene, or a propylene spacer. |
35(0,1,1,5) |
Details |