Protein Information

Name A10
Synonyms A10; IGKV6D 21; IGKV6D21; immunoglobulin kappa variable 6D 21; immunoglobulin kappa variable 6D 21s

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
20217595 Chan JM, Valencia PM, Zhang L, Langer R, Farokhzad OC: Polymeric nanoparticles for drug delivery. Methods Mol Biol. 2010;624:163-75.

In this chapter, we describe the methods of (1) preparation and characterization of drug-encapsulated polymeric NPs formulated with biocompatible and biodegradable poly (D,L-lactic-co-glycolic acid)-poly (ethylene glycol) (PLGA-b-PEG) copolymers; (2) surface functionalization of the polymeric NPs with the A10 2'-fluoropyrimidine ribonucleic acid (RNA) aptamers that recognize the prostate-specific membrane antigen (PSMA) on prostate cancer cells; and (3) evaluation of the binding properties of these targeted polymeric NPs to PSMA-expressing prostate cancer cells in vitro and in vivo.
31(0,1,1,1) Details
19488725 Gu F, Langer R, Farokhzad OC: Formulation/preparation of functionalized nanoparticles for in vivo targeted drug delivery. Methods Mol Biol. 2009;544:589-98.

Here we describe the preparation of drug-encapsulated nanoparticles formulated with biocompatible and biodegradable poly (D: ,L: -lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-b-PEG) copolymer and surface functionalized with the A10 2-fluoropyrimidine ribonucleic acid aptamers that recognize the extracellular domain of prostate-specific membrane antigen (PSMA), a well-characterized antigen expressed on the surface of prostate cancer cells.
31(0,1,1,1) Details