Protein Information

Name integrin alpha v
Synonyms CD51; CD51 antigen; ITGAV; Integrin alpha V; Integrin alpha V precursor; MSK 8; MSK8; VNRA…

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
20056123 Zhan C, Gu B, Xie C, Li J, Liu Y, Lu W: Cyclic RGD conjugated poly (ethylene glycol)-co-poly (lactic acid) micelle enhances paclitaxel anti-glioblastoma effect. J Control Release. 2010 Apr 2;143(1):136-42. Epub 2010 Jan 7.

To employ the high binding affinity of a cyclic RGD peptide (c (RGDyK), cyclic Arginine-Glycine-Aspartic acid-D-Tyrosine-Lysine) with integrin alpha (v) beta (3) over-expressed on tumor neovasculature and U87MG glioblastoma cells, we prepared paclitaxel-loaded c (RGDyK)-Poly (ethylene glycol)-block-poly (lactic acid) micelle (c (RGDyK)-PEG-PLA-PTX).
32(0,1,1,2) Details
19747725 Benton JA, Fairbanks BD, Anseth KS: Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels. Biomaterials. 2009 Dec;30(34):6593-603. Epub 2009 Sep 10.

Thus, a matrix metalloproteinase (MMP) degradable poly (ethylene glycol) (PEG) hydrogel system is proposed in this communication as a useful tool for characterizing VIC function in 3D.
As RGD concentration increased from 0 to 2000 microM, VIC process extension and integrin alpha (v) beta (3) binding increased within two days.
1(0,0,0,1) Details