Protein Information

Name integrins
Synonyms Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s…

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
19527117 Wang Y, Wang X, Zhang Y, Yang S, Wang J, Zhang X, Zhang Q: RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells. J Drug Target. 2009 Jul;17(6):459-67.

In this study, an integrin alphavbeta3 and alphavbeta5 binding tripeptide, RGD (Arg-Gly-Asp), was conjugated with the surface of poly (ethylene glycol)-block-poly (D,L-lactide) (PEG-PLA) micelles.
34(0,1,1,4) Details
19481795 Beamish JA, Fu AY, Choi AJ, Haq NA, Kottke-Marchant K, Marchant RE: The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype. Biomaterials. 2009 Sep;30(25):4127-35. Epub 2009 May 29.

This study reports on the ability of poly (ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds with pendant integrin-binding GRGDSP peptides (RGD-gels) to support the re-differentiation of cultured vascular smooth muscle cells (SMCs) toward a contractile phenotype.
6(0,0,1,1) Details
19747725 Benton JA, Fairbanks BD, Anseth KS: Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels. Biomaterials. 2009 Dec;30(34):6593-603. Epub 2009 Sep 10.

Thus, a matrix metalloproteinase (MMP) degradable poly (ethylene glycol) (PEG) hydrogel system is proposed in this communication as a useful tool for characterizing VIC function in 3D.
Additionally, fibronectin derived pendant RGD was incorporated into the system to promote integrin binding.
2(0,0,0,2) Details
19623580 Gigout A, Levasseur S, Girard-Lauriault PL, Buschmann MD, Wertheimer MR, Jolicoeur M: CHO cells adhering to nitrogen-rich plasma-polymerised ethylene exhibit high production of a specific recombinant protein. Macromol Biosci. 2009 Oct 8;9(10):979-88.

Finally, cell adhesion on PPE:N surfaces was found to be independent of integrins, and was probably mediated by certain non-specific interactions with the PPE:N surface.
1(0,0,0,1) Details
19545894 George PA, Doran MR, Croll TI, Munro TP, Cooper-White JJ: Nanoscale presentation of cell adhesive molecules via block copolymer self-assembly. Biomaterials. 2009 Sep;30(27):4732-7. Epub 2009 Jul 9.

Recently, the control of integrin spacing and cellular shape has been shown to affect fundamental biological processes, such as differentiation and apoptosis.
Here, we present the self-assembly of maleimide functionalised polystyrene-block-poly (ethylene oxide) copolymers as a simple, yet highly precise method for controlling the position of cellular adhesion molecules.
1(0,0,0,1) Details
19699245 Danhier F, Vroman B, Lecouturier N, Crokart N, Pourcelle V, Freichels H, Jerome C, Marchand-Brynaert J, Feron O, Preat V: Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel. J Control Release. 2009 Dec 3;140(2):166-73. Epub 2009 Aug 20.


We observed in vitro that RGD-grafted nanoparticles were more associated to human umbilical vein endothelial cells (HUVEC) by binding to alpha (v) beta (3) integrin than non-targeted nanoparticles.
1(0,0,0,1) Details
19482300 Raffetto JD, Barros YV, Wells AK, Khalil RA: MMP-2 induced vein relaxation via inhibition of [Ca2+] e-dependent mechanisms of venous smooth muscle contraction. J Surg Res. 2010 Apr;159(2):755-64. Epub 2008 Oct 24.

To test the role of Ca (2+) release from the sarcoplasmic reticulum, IVC was incubated in Ca (2+)-free 2 mM ethylene glycol-bis (2-aminoethyl ether-N,N,N',N'-tetra-acetic acid (EGTA) Krebs with or without MMP-2.
To test whether MMP-2 actions involve generation of RGD and modulation of integrin receptors, experiments where repeated in IVC segments saturated with RGD (10 (-5) M), or pretreated with the alpha (v) beta (3) integrin blocker cyclo (Ala-Arg-Gly-Asp-3-aminomethylbenzoyl) (cyclo-RGD).
1(0,0,0,1) Details
19476331 Merkel OM, Germershaus O, Wada CK, Tarcha PJ, Merdan T, Kissel T: Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly (ethylene imine). Bioconjug Chem. 2009 Jun;20(6):1270-80.
162(2,2,2,2) Details
20128995 Liu Z, Liu S, Niu G, Wang F, Liu S, Chen X: Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra (ethylene glycol) linkers. Mol Imaging. 2010 Feb;9(1):21-9.
117(1,2,2,7) Details
19575417 Rosca EV, Gillies RJ, Caplan MR: Glioblastoma targeting via integrins is concentration dependent. Biotechnol Bioeng. 2009 Oct 1;104(2):408-17.

In this study we investigated the binding specificity of a multivalent construct including three peptides segments (TWYKIAFQRNRK), which bind the alpha (6) beta (1)-integrin, linked by poly (ethylene glycol) spacers.
82(1,1,1,2) Details
19818492 Xiong XB, Ma Z, Lai R, Lavasanifar A: The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin. Biomaterials. 2010 Feb;31(4):757-68. Epub 2009 Oct 8.

Towards this goal, two polymeric DOX nano-conjugates were developed, for which the design was based on the use of multi-functionalized poly (ethylene oxide)-block-poly (epsilon-caprolactone) (PEO-b-PCL) micelles decorated with alphavbeta3 integrin-targeting ligand (i.e.
81(1,1,1,1) Details