| 19560813 |
Lin CC, Metters AT, Anseth KS: Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14. Epub 2009 Jun 27.
Here, we report the synthesis, characterization, and application of peptide-functionalized, cytokine-antagonizing poly (ethylene glycol) (PEG) hydrogels capable of sequestering the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFalpha). |
34(0,1,1,4) |
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| 19896998 |
Navath RS, Wang B, Kannan S, Romero R, Kannan RM: Stimuli-responsive star poly (ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation. J Control Release. 2010 Mar 19;142(3):447-56. Epub 2009 Nov 5.
The conjugates showed significant increase in antioxidant activity (more than a factor of 2) compared to free drug as seen from the inhibition of LPS induced ROS, NO, GSH and tumor necrosis factor-alpha (TNF-alpha) release in microglial cells. |
1(0,0,0,1) |
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