Protein Information

Name bone morphogenetic protein 2
Synonyms BMP 2; BMP 2A; BMP2; BMP2A; Bone morphogenetic protein 2 precursor; bone morphogenetic protein 2; Bone morphogenetic protein 2 precursors; bone morphogenetic protein 2s

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
19767180 Kang SM, Kong B, Oh E, Choi JS, Choi IS: Osteoconductive conjugation of bone morphogenetic protein-2 onto titanium/titanium oxide surfaces coated with non-biofouling poly (poly (ethylene glycol) methacrylate). Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):385-9. Epub 2009 Sep 1.

Titanium substrates were coated with a non-biofouling poly (poly (ethylene glycol) methacrylate) (pPEGMA) by surface-initiated polymerization, and bone morphogenetic protein-2 (BMP-2) was chemically conjugated to the activated pPEGMA films.
113(1,2,2,3) Details
20158316 Wang G, Kucharski C, Lin X, Uludag H: Bisphosphonate-coated BSA nanoparticles lack bone targeting after systemic administration. J Drug Target. 2010 Feb 16.

A polymeric conjugate of polyethyleneimine-graft-poly (ethylene glycol) and 2-(3-mercaptopropylsulfanyl)-ethyl-1,1-bisphosphonic acid (PEI-PEG-thiolBP) was prepared and used for surface coating of bovine serum albumin (BSA) nanoparticles (NPs) designed for bone-specific delivery of bone morphogenetic protein-2 (BMP-2).
31(0,1,1,1) Details
20232367 Mercado AE, Jabbari E: Effect of encapsulation or grafting on release kinetics of recombinant human bone morphogenetic protein-2 from self-assembled poly (lactide-co-glycolide ethylene oxide fumarate) nanoparticles. Microsc Res Tech. 2010 Mar 15.
12(0,0,2,2) Details
19775743 Jha AK, Yang W, Kirn-Safran CB, Farach-Carson MC, Jia X: Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release. Biomaterials. 2009 Dec;30(36):6964-75. Epub 2009 Sep 23.

We have developed a biomimetic growth factor delivery system that effectively stimulates the chondrogenic differentiation of the cultured mesenchymal stem cells via the controlled presentation of bone morphogenetic protein-2 (BMP-2).
Recombinantly produced, heparan sulfate (HS)-bearing perlecan domain I (PlnDI) was covalently immobilized to HA HGPs (HGP-P (1)) via a flexible poly (ethylene glycol) (PEG) linker through the lysine amines in the core protein of PlnDI employing reductive amination.
1(0,0,0,1) Details
19912653 Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, La Marca F, Lin CY: Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res Ther. 2009;11(6):R172. Epub 2009 Nov 13.

METHODS : 30 rats that underwent 21 G needle-puncture at rat tail discs were injected with simvastatin-loaded poly (ethylene glycol)-poly (lactic acid-co-glycolic acid)-poly (ethylene glycol) (PEG-PLGA-PEG) gel (5 mg/ml) or vehicle control at 4 weeks after needle injury.
Bone morphogenetic protein-2 (BMP-2), aggrecan, collagen type II, and collagen type I messenger ribonucleic acid (mRNA) expression in the rat nucleus pulposus (NP) were measured by real-time polymerase chain reaction (PCR).
1(0,0,0,1) Details
20345129 Betz MW, Yeatts AB, Richbourg WJ, Caccamese JF, Coletti DP, Falco EE, Fisher JP: Macroporous Hydrogels Upregulate Osteogenic Signal Expression and Promote Bone Regeneration. Biomacromolecules. 2010 Mar 26.

In particular, we have proposed a tissue engineering approach for orbital bone repair based on a cyclic acetal biomaterial formed from 5-ethyl-5-(hydroxymethyl)-beta,beta-dimethyl-1,3-dioxane-2-ethanol diacrylate (EHD) and poly (ethylene glycol) diacrylate (PEGDA).
The viability of hMSCs, the expression of bone morphogenetic protein-2 (BMP-2), BMP receptor type 1A, and BMP receptor type 2 by hMSCs, and the differentiation of hMSCs were then assessed.
1(0,0,0,1) Details
19878992 Zhang S, Kucharski C, Doschak MR, Sebald W, Uludag H: Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery. Biomaterials. 2010 Feb;31(5):952-63. Epub 2009 Oct 29.

Bone Morphogenetic Protein-2 (BMP-2) plays an important role in stimulating new bone formation, and has been utilized in clinical bone repair by implantation.
In this study, we report a nanoparticulate (NP) system for BMP-2 delivery based on bovine serum albumin (BSA) NPs stabilized with a poly (ethylene glycol) modified polyethylenimine (PEI-PEG) coating.
1(0,0,0,1) Details