Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
19508905 Villanueva I, Weigel CA, Bryant SJ: Cell-matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogels. Acta Biomater. 2009 Oct;5(8):2832-46. Epub 2009 Jun 7.

To better understand chondrocytes interactions with their PCM, three-dimensional poly (ethylene glycol) (PEG) hydrogels containing Arg-Gly-Asp (RGD), the cell-adhesion sequence found in fibronectin and which is present in the PCM of cartilage, were employed.
31(0,1,1,1) Details
19556003 Young TH, Tu HR, Chan CC, Huang YC, Yen MH, Cheng NC, Chiu HC, Lin SJ: The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility. Biomaterials. 2009 Oct;30(28):5031-40. Epub 2009 Jun 24.

This study is aimed at tackling this dilemma by extracellular matrix (ECM) protein coating of a lower adhesive substratum poly (ethylene-co-vinyl alcohol) (EVAL) that has been shown to facilitate hair follicle dermal papilla (DP) spheroid formation.
We found that coating with either fibronectin (Fn), collagen I, or collagen IV yields higher adhesivity and cell growth than that with laminin.
1(0,0,0,1) Details
19747725 Benton JA, Fairbanks BD, Anseth KS: Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels. Biomaterials. 2009 Dec;30(34):6593-603. Epub 2009 Sep 10.

Thus, a matrix metalloproteinase (MMP) degradable poly (ethylene glycol) (PEG) hydrogel system is proposed in this communication as a useful tool for characterizing VIC function in 3D.
Additionally, fibronectin derived pendant RGD was incorporated into the system to promote integrin binding.
1(0,0,0,1) Details
19702281 Mansouri S, Fatisson J, Miao Z, Merhi Y, Winnik FM, Tabrizian M: Silencing Red Blood Cell Recognition toward Anti-A Antibody by Means of Polyelectrolyte Layer-by-Layer Assembly in a Two-Dimensional Model System (dagger). Langmuir. 2009 Aug 24.

Using a two-dimensional (2D) model whereby nonfixed RBCs are adsorbed on a human fibronectin (HFN)-coated surface, we demonstrate that the layer-by-layer (LbL) assembly technique of biocompatible polyelectrolytes can be employed to achieve the immunocamouflage of RBCs against the Anti-A antibody while maintaining the integrity and viability of the cells.
The multilayered film consisted of a protecting shell (P-shell), containing five bilayers of chitosan-graft-phosphorylcholine (CH-PC) and sodium hyaluronate (HA), covered by a camouflage shell (C-shell) made up of five bilayers of poly-(l-lysine)-graft-poly (ethylene glycol) (PLL-PEG) and alginate (AL).
1(0,0,0,1) Details
20203158 Shimizu H, Hori Y, Kaname S, Yamada K, Nishiyama N, Matsumoto S, Miyata K, Oba M, Yamada A, Kataoka K, Fujita T: siRNA-Based Therapy Ameliorates Glomerulonephritis. . J Am Soc Nephrol. 2010 Apr;21(4):622-33. Epub 2010 Mar 4.

Here, we developed a system to target delivery of siRNAs to glomeruli via poly (ethylene glycol)-poly (l-lysine)-based vehicles.
Furthermore, this therapy reduced the expression of the profibrotic markers TGF-beta1, plasminogen activator inhibitor-1, and fibronectin.
1(0,0,0,1) Details
19573910 Niepel MS, Peschel D, Sisquella X, Planell JA, Groth T: pH-dependent modulation of fibroblast adhesion on multilayers composed of poly (ethylene imine) and heparin. Biomaterials. 2009 Oct;30(28):4939-47. Epub 2009 Jul 1.

While plain terminal layers were rather cytophobic, the pre-adsorption of serum or fibronectin (FN) caused a distinct change in cell morphology in dependence on the pH setup.
1(0,0,0,1) Details
19481795 Beamish JA, Fu AY, Choi AJ, Haq NA, Kottke-Marchant K, Marchant RE: The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype. Biomaterials. 2009 Sep;30(25):4127-35. Epub 2009 May 29.

This study reports on the ability of poly (ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds with pendant integrin-binding GRGDSP peptides (RGD-gels) to support the re-differentiation of cultured vascular smooth muscle cells (SMCs) toward a contractile phenotype.
Human coronary artery SMCs were seeded on RGD-gels, hydrogels with other extracellular matrix derived peptides, fibronectin (FN) and laminin (LN).
1(0,0,0,1) Details
20039374 Powers DE, Millman JR, Bonner-Weir S, Rappel MJ, Colton CK: Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog. 2009 Dec 28.

Here, we demonstrate theoretically that highly oxygen-permeable silicone rubber membranes can be used to control pO (2cell) during culture of cells in monolayers and aggregates much more accurately and can achieve more rapid transient response following a disturbance than on polystyrene and fluorinated ethylene-propylene copolymer membranes.
Cell attachment on silicone rubber was achieved by physical adsorption of fibronectin or Matrigel.
1(0,0,0,1) Details
20181561 Alves CM, Reis RL, Hunt JA: The competitive adsorption of human proteins onto natural-based biomaterials. J R Soc Interface. 2010 Feb 24.

Polymeric blends of starch and cellulose acetate, polycaprolactone (SPCL) and ethylene vinyl alcohol (SEVA-C) were used.
Different proteins, bovine serum albumin, human serum albumin (HSA) and human fibronectin (HFN), were selected for this study.
1(0,0,0,1) Details
20345129 Betz MW, Yeatts AB, Richbourg WJ, Caccamese JF, Coletti DP, Falco EE, Fisher JP: Macroporous Hydrogels Upregulate Osteogenic Signal Expression and Promote Bone Regeneration. Biomacromolecules. 2010 Mar 26.


In particular, we have proposed a tissue engineering approach for orbital bone repair based on a cyclic acetal biomaterial formed from 5-ethyl-5-(hydroxymethyl)-beta,beta-dimethyl-1,3-dioxane-2-ethanol diacrylate (EHD) and poly (ethylene glycol) diacrylate (PEGDA).
0(0,0,0,0) Details