Protein Information

Name VEGF
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name ethylene
CAS ethene

Reference List

PubMed Abstract RScore(About this table)
20178335 Oba M, Vachutinsky Y, Miyata K, Kano MR, Ikeda S, Nishiyama N, Itaka K, Miyazono K, Koyama H, Kataoka K: Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1. Mol Pharm. 2010 Mar 17.

Poly (ethylene glycol)-poly (l-lysine) block copolymers (PEG-PLys) with thiol groups in the side chain of the PLys segment were synthesized and applied for preparation of disulfide cross-linked polyplex micelles through ion complexation with plasmid DNA (pDNA) encoding the soluble form of vascular endothelial growth factor (VEGF) receptor-1 (sFlt-1), which is a potent antiangiogenic molecule.
31(0,1,1,1) Details
19723440 Leslie-Barbick JE, Moon JJ, West JL: Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly (ethylene glycol) diacrylate hydrogels. J Biomater Sci Polym Ed. 2009;20(12):1763-79.
12(0,0,1,7) Details
19554729 Christman KL, Vazquez-Dorbatt V, Schopf E, Kolodziej CM, Li RC, Broyer RM, Chen Y, Maynard HD: Nanoscale growth factor patterns by immobilization on a heparin-mimicking polymer. J Am Chem Soc. 2008 Dec 10;130(49):16585-91.

Poly (sodium 4-styrenesulfonate-co-poly (ethylene glycol) methacrylate) (pSS-co-pPEGMA) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization using ethyl S-thiobenzoyl-2-thiopropionate as a chain transfer agent and 2,2'-azoisobutyronitrile (AIBN) as the initiator.
Binding of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) to the polymer via the heparin binding domains was then confirmed by surface plasmon resonance (SPR).
2(0,0,0,2) Details
20170425 Yang B, Zhang Y, Zhou LH, Sun ZY, Zheng JH, Chen Y, Dai YT: Development of a porcine bladder acellular matrix with well preserved extracellular bioactive factors for tissue engineering. Tissue Eng Part C Methods. 2010 Feb 22.

Meanwhile, several preservative techniques, including limitation of wash time, supplement with inhibitors of proteinase, control of the pH value and temperature of the wash buffer, ethylene oxide sterilization and lyophilization of the scaffold for storage, were used to protect the extracellular bioactive factors.
It was also found that the amount of two representative bioactive factors, platelet-derived growth factor BB (PDGF-BB) and vascular endothelial growth factor (VEGF), was positively correlated with the sulfated GAG content in the porcine BAM, implying that the amount of sulfated GAG might be a determinant for preservation of bioactive factors in the decellularized tissues.
1(0,0,0,1) Details
20053444 Yu DH, Lu Q, Xie J, Fang C, Chen HZ: Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature. Biomaterials. 2010 Mar;31(8):2278-92. Epub 2010 Jan 6.

We synthesized the aldehyde poly (ethylene glycol)-poly (lactide) (aldehyde-PEG-PLA) block copolymer by ring opening polymerization.
K237 ligand, a peptide that can bind to the KDR receptors predominantly expressed on the surface of tumor neovasculature endothelial cells with high affinity and specificity and inhibit the VEGF-KDR angiogenic signal pathway, was conjugated to the aldehyde group of PEG chain using the N-terminal PEGylation technique.
1(0,0,0,1) Details
20009166 Shen Y, Peng H, Pan S, Feng M, Wen Y, Deng J, Luo X, Wu C: Interaction of DNA/nuclear protein/polycation and the terplexes for gene delivery. Nanotechnology. 2010 Jan 29;21(4):045102. Epub 2009 Dec 10.


The percentage of GFP-transfected cells and VEGF protein expression level induced by HMGB1/PEG-PEI were 2.6-4.9-fold and 1.4-2.8-fold higher, respectively, than that of a common cationic polymer PEI 25 kDa.
1(0,0,0,1) Details