Protein Information

Name prothrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name difethialone
CAS

Reference List

PubMed Abstract RScore(About this table)
19752778 Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50.

RESULTS AND CONCLUSION: In this manuscript we report the prothrombin times measured in the F7 generation after exposure to chlorophacinone, bromadiolone, difenacoum and difethialone.
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9477532 Robben JH, Kuijpers EA, Mout HC: Plasma superwarfarin levels and vitamin K1 treatment in dogs with anticoagulant rodenticide poisoning. Vet Q. 1998 Jan;20(1):24-7.

The dose of vitamin K1 was reduced in a stepwise manner as long as the prothrombin time remained within physiological limits.
Brodifacoum, difethialone, and difenacoum were detected by high-performance liquid chromatography (HPLC) in the plasma of 13, 3, and 2 dogs, respectively.
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11016065 Vasquez A, Rodriguez MA: [Hemorrhagic syndrome caused by exposure to a rodenticide. Rev Med Chil. 2000 Jun;128(6):647-9.

We report a 22 years old male, admitted to the emergency room due to a life threatening coagulation disorder, with prothrombin times fluctuation between 5 and 37% and very low activity of factors II, VII, IX and X.
In the month prior to the admission, the patient had used the rodenticide difethialone, without any precaution to avoid accidental exposure.
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