Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
15659565 Carvajal F, Sanchez-Amate MC, Sanchez-Santed F, Cubero I: Neuroanatomical targets of the organophosphate chlorpyrifos by c-fos immunolabeling. Toxicol Sci. 2005 Apr;84(2):360-7. Epub 2005 Jan 19.
33(0,1,1,3) Details
17190973 Carvajal F, Lopez-Grancha M, Navarro M, Sanchez-Amate Mdel C, Cubero I: Long-lasting reductions of ethanol drinking, enhanced ethanol-induced sedation, and decreased c-fos expression in the Edinger-Westphal nucleus in Wistar rats exposed to the organophosphate chlorpyrifos. Toxicol Sci. 2007 Apr;96(2):310-20. Epub 2006 Dec 26.
7(0,0,1,2) Details
12464398 Dam K, Seidler FJ, Slotkin TA: Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics. Brain Res Bull. 2003 Jan 15;59(4):261-5.

In the current study, we examined mRNAs encoding c-fos and p53, in order to determine if changes in these factors correspond to the differential susceptibility of forebrain neurons and glia, when exposure is shifted from the early neonatal period (postnatal days 1-4) to a later period (days 11-14).
2(0,0,0,2) Details
17893397 Betancourt AM, Filipov NM, Carr RL: Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol Sci. 2007 Dec;100(2):445-55. Epub 2007 Sep 24.

On PND12, c-fos mRNA, a marker of neuronal activation, was increased in both regions.
1(0,0,0,1) Details