| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | cyhalothrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17974266 | Zhang YL, Mu W, Chen ZL, Han ZR, Ma C, Zhai RH: [Susceptibility and related physiological and biochemical mechanisms of Carposina niponensis Walsingham larvae on six insecticides before and after overwintering]. Ying Yong Sheng Tai Xue Bao. 2007 Aug;18(8):1913-6. The study with impregnating method showed that after overwintering, the susceptibility of Carposina niponensis larvae on triazophos, phoxim, chlorpyrifos, malathion, lambda-cyhalothrin and abamectin was 34.50, 16.71, 3.89, 3.28, 5.90 and 2.73 times as much as that before overwintering, the total protein, and fat contents and carboxylesterase, acid phosphatase, alkaline phosphatase, glutathione-S-transferase, superoxide dismutase, catalase and peroxidase activities in C. niponensis larvae were decreased by 17.10%, 41.76% and 30.08%, 62.36%, 53.47%, 76.19%, 80.60%, 18.77%, 14.16% and 64.02%, respectively, and the activity of acetylcholinesterase, the target enzyme of many insecticides, was 1.41 times as much as that before overwintering. |
31(0,1,1,1) | Details |
| 19735994 | Fetoui H, Makni M, Mouldi Garoui E, Zeghal N: Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of Exp Toxicol Pathol. 2009 Sep 5. The activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were significantly decreased due to lambda-cyhalothrin exposure. |
6(0,0,1,1) | Details |
| 11603736 | Yang X, Zhu KY, Buschman LL, Margolies DC: Comparative susceptibility and possible detoxification mechanisms for selected miticides in banks grass mite and two-spotted spider mite (Acari: Tetranychidae). Exp Appl Acarol. 2001;25(4):293-9. The significant synergism with these pyrethroids of all three tested synergists (except for DEM with lambda-cyhalothrin against TSM) suggests that esterases, glutathione S-transferases, and cytochrome P450 monooxygenases all play important roles in their detoxification. |
6(0,0,1,1) | Details |
| 11415437 | Vontas JG, Small GJ, Hemingway J: Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens. Biochem J. 2001 Jul 1;357(Pt 1):65-72. Selection of a laboratory colony of the brown planthopper Nilaparvata lugens with the pyrethroids permethrin and lambda-cyhalothrin increased its resistance to both insecticides. |
2(0,0,0,2) | Details |
| 19422890 | Lo Piero AR, Mercurio V, Puglisi I, Petrone G: Gene isolation and expression analysis of two distinct sweet orange [Citrus sinensis L. (Osbeck)] tau-type glutathione transferases. Gene. 2009 Aug 15;443(1-2):143-50. Epub 2009 May 5. Furthermore, we also showed that the expression of U1 gene was remarkably induced in response to cadmium sulphate, CDNB and cyhalothrin treatments as well as to cold stress. Glutathione S-transferases (GSTs) represent a multifunctional family of enzymes grouped into four main classes (tau, phi, theta, and zeta) conjugating endobiotic and xenobiotic compounds to |
2(0,0,0,2) | Details |
| 20138202 | Yousef MI: modulates reproductive toxicity of pyrethroid lambda-cyhalothrin in male rabbits. Food Chem Toxicol. 2010 Feb 4. While, activities of glutathione S-transferase (GST), transaminases and acid phosphatase (AcP) were significantly decreased. |
1(0,0,0,1) | Details |
| 16937654 | Johnson RM, Wen Z, Schuler MA, Berenbaum MR: Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. J Econ Entomol. 2006 Aug;99(4):1046-50. Although some pyrethroids, such as cyfluthrin and lambda-cyhalothrin, are highly toxic to honey bees, the toxicity of tau-fluvalinate is low enough to warrant its use to control parasitic mites inside honey bee colonies. Metabolic insecticide resistance in other insects is mediated by three major groups of detoxifying enzymes: the cytochrome P450 monooxygenases (P450s), the carboxylesterases (COEs), and the glutathione S-transferases (GSTs). |
1(0,0,0,1) | Details |
| 11332829 | Yang X, Margolies DC, Zhu KY, Buschman LL: Host plant-induced changes in detoxification enzymes and susceptibility to pesticides in the twospotted spider mite (Acari: Tetranychidae). J Econ Entomol. 2001 Apr;94(2):381-7. Susceptibility of mites on cucumber to the synthetic pyrethroids bifenthrin and lambda-cyhalothrin was greater than that of mites reared on lima bean and maize after only 24 h on the plants, and remained higher after 7 d. Susceptibility was inversely related to activities of both general esterase and glutathione S-transferase (GST) in mites on cucumber; general esterase and GST activities were 60 and 25% lower, respectively, than activities of twospotted spider mite on lima bean after 7 d of feeding. |
1(0,0,0,1) | Details |
| 18755020 | Perera MD, Hemingway J, Karunaratne SP: Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka. Malar J. 2008 Aug 28;7:168. METHODS: Adult females were exposed to the WHO discriminating dosages of DDT, malathion, fenitrothion, propoxur, lambda-cyhalothrin, cyfluthrin, cypermethrin, deltamethrin, permethrin and etofenprox. The presence of metabolic resistance by esterase, glutathione S-transferase (GST) and monooxygenase-based mechanisms, and the sensitivity of the acetylcholinesterase target site were assessed using synergists, and biochemical, and metabolic techniques. |
1(0,0,0,1) | Details |
| 17370803 | Booth LH, Wratten SD, Kehrli P: Effects of reduced rates of two insecticides on enzyme activity and mortality of an aphid and its lacewing predator. J Econ Entomol. 2007 Feb;100(1):11-9. The effects of reduced application rates of the insecticides lambda-cyhalothrin and dimethoate on the mortality of bird cherry-oat aphid, Rhopalosiphon padi (L.), and lacewing Micromus tasmaniae Walker were determined in the laboratory and field. Cholinesterase (ChE) and glutathione S-transferase (GST) activities in survivors provided a measure of sublethal effects and general fitness. |
1(0,0,0,1) | Details |
| 19274371 | Fonseca-Gonzalez I, Quinones ML, McAllister J, Brogdon WG: Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz. 2009 Feb;104(1):18-26. Enzyme levels related to insecticide resistance, including mixed function oxidases (MFO), non-specific esterases (NSE), glutathione S-transferases and modified acetylcholinesterase were evaluated in all populations and compared with a susceptible natural strain. |
1(0,0,0,1) | Details |
| 10661713 | Valles SM, Koehler PG, Brenner RJ: Comparative insecticide susceptibility and detoxification enzyme activities among pestiferous blattodea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Nov;124(3):227-32. Topical bioassays using propoxur, chlorpyrifos, and lambda-cyhalothrin were conducted on eight cockroach species. Propoxur LD50 was significantly (P = 0.01; r = 0.81) correlated with glutathione S-transferase activity. |
1(0,0,0,1) | Details |
| 12680930 | Brengues C, Hawkes NJ, Chandre F, McCarroll L, Duchon S, Guillet P, Manguin S, Morgan JC, Hemingway J: Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene. Med Vet Entomol. 2003 Mar;17(1):87-94. Direct neurophysiological assays on individual larvae from three strains with these mutations demonstrated reduced nerve sensitivity to permethrin or lambda cyhalothrin inhibition compared to the susceptible strains. Glutathione S-transferase activity was elevated in the Guyane strain. |
1(0,0,0,1) | Details |
| 8294621 | Hemingway J, Dunbar SJ, Monro AG, Small GJ: Pyrethroid resistance in German cockroaches (Dictyoptera: Blattelidae): resistance levels and underlying mechanisms. J Econ Entomol. 1993 Dec;86(6):1631-8. Greater than 2-fold resistance to the pyrethroids cyfluthrin, fenvalerate, cypermethrin, and lambda cyhalothrin appeared in 15 of these strains. Possible resistance mechanisms detected in these populations included elevated levels of cytochrome P450, general esterase and glutathione S-transferase, and nerve insensitivity (kdr-type resistance). |
1(0,0,0,1) | Details |
| 17137748 | El-Demerdash FM: Lambda-cyhalothrin-induced changes in oxidative stress biomarkers in rabbit erythrocytes and alleviation effect of some antioxidants. Toxicol In Vitro. 2007 Apr;21(3):392-7. Epub 2006 Oct 1. However, a significant decrease in the content of sulfhydryl groups (SH-groups), and the activities of acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) were observed. |
1(0,0,0,1) | Details |
| 15849966 | Rodriguez MM, Bisset JA, Diaz C, Soca LA: [Cross resistance to pyrethroids in Aedes aegypti from Cuba induced by the selection with organophosphate malathion]. Rev Cubana Med Trop. 2003 May-Aug;55(2):105-11. It was also observed cross resistance to other pyrethroids (lambda-cyhalothrin, cypermethrin and ciflutrine). Nevertheless, there was an increase in the frequency of the glutathione-s-transferase mechanism from 0.049 in Santiago de Cuba to 0.42 in SAN-F5, which may be associated with the resistance to pyrethroids. |
1(0,0,0,1) | Details |
| 10774652 | Karunaratne SH: Insecticide cross-resistance spectra and underlying resistance mechanisms of Sri Lankan anopheline vectors of malaria. Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):460-9. Higher glutathione-S-transferase activity was marked in An. subpictus. Adults were also tested for WHO standard discriminating dosages of malathion, propoxur, permethrin, DDT, cypermethrin, deltamethlin and lambda cyhalothrin. |
1(0,0,0,1) | Details |
| 16134975 | Hunt RH, Brooke BD, Pillay C, Koekemoer LL, Coetzee M: Laboratory selection for and characteristics of pyrethroid resistance in the malaria vector Anopheles funestus. Med Vet Entomol. 2005 Sep;19(3):271-5. A subsample of the colony was selected for pyrethroid resistance using 0.1% lambda-cyhalothrin. |
0(0,0,0,0) | Details |