| Name | sodium channel (protein family or complex) |
|---|---|
| Synonyms | Sodium channel |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18561309 | Davies TE, O'Reilly AO, Field LM, Wallace B, Williamson MS: Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling. Pest Manag Sci. 2008 Nov;64(11):1126-30. Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes. |
7(0,0,1,2) | Details |
| 16828989 | Xu Q, Wang H, Zhang L, Liu N: Sodium channel gene expression associated with pyrethroid resistant house flies and German cockroaches. Gene. 2006 Sep 1;379:62-7. Epub 2006 May 4. |
3(0,0,0,3) | Details |
| 17487686 | Davies TG, Field LM, Usherwood PN, Williamson MS: DDT, pyrethrins, pyrethroids and insect channels. IUBMB Life. 2007 Mar;59(3):151-62. DDT, the pyrethrins and the synthetic pyrethroids (the latter currently accounting for around 17% of the world insecticide market), act on the voltage-gated sodium channel proteins found in insect nerve cell membranes. |
3(0,0,0,3) | Details |
| 18252244 | SupYoon K, Symington SB, Hyeock Lee S, Soderlund DM, Marshall Clark J: Three mutations identified in the voltage-sensitive sodium channel alpha-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 channels expressed in Xenopus oocytes. Insect Biochem Mol Biol. 2008 Mar;38(3):296-306. Epub 2007 Dec 4. |
3(0,0,0,3) | Details |
| 16475981 | O'Reilly AO, Khambay BP, Williamson MS, Field LM, Wallace BA, Davies TG: Modelling insecticide-binding sites in the voltage-gated sodium channel. . Biochem J. 2006 Jun 1;396(2):255-63. |
3(0,0,0,3) | Details |
| 18801327 | Rajatileka S, Black WC 4th, Saavedra-Rodriguez K, Trongtokit Y, Apiwathnasorn C, McCall PJ, Ranson H: Development and application of a simple colorimetric assay reveals widespread distribution of sodium channel mutations in Thai populations of Aedes aegypti. Acta Trop. 2008 Oct;108(1):54-7. Epub 2008 Aug 29. |
2(0,0,0,2) | Details |
| 18391234 | Rajesh R, Gunasekaran K, Muthukumaravel S, Balaraman K, Jambulingam P: In Silico analysis of voltage-gated sodium channel in relation to DDT resistance in vector mosquitoes. In Silico Biol. 2007;7(4-5):413-21. |
2(0,0,0,2) | Details |
| 17433068 | Davies TG, Field LM, Usherwood PN, Williamson MS: A comparative study of voltage-gated channels in the Insecta: implications for pyrethroid resistance in Anopheline and other Neopteran species. Insect Mol Biol. 2007 Jun;16(3):361-75. Epub 2007 Apr 13. We report the complete cDNA sequence of the Anopheles gambiae voltage-gated sodium channel (VGSC) alpha-subunit isolated from mature adult mosquitoes. |
2(0,0,0,2) | Details |
| 19594947 | Singh OP, Bali P, Hemingway J, Subbarao SK, Dash AP, Adak T: PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato. Malar J. 2009 Jul 14;8:154. Knock-down resistance due to a point mutation in the voltage gated sodium channel at L1014 residue (kdr) is a common mechanism of resistance to DDT and pyrethroids. |
2(0,0,0,2) | Details |
| 17991435 | Usherwood PN, Davies TG, Mellor IR, O'Reilly AO, Peng F, Vais H, Khambay BP, Field LM, Williamson MS: Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT. FEBS Lett. 2007 Nov 27;581(28):5485-92. Epub 2007 Nov 6. |
2(0,0,0,2) | Details |
| 18402142 | Reimer L, Fondjo E, Patchoke S, Diallo B, Lee Y, Ng A, Ndjemai HM, Atangana J, Traore SF, Lanzaro G, Cornel AJ: Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae. J Med Entomol. 2008 Mar;45(2):260-6. Two mutations at the same locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. |
1(0,0,0,1) | Details |
| 16608487 | Pinto J, Lynd A, Elissa N, Donnelly MJ, Costa C, Gentile G, Caccone A, do Rosario VE: Co-occurrence of East and West African kdr mutations suggests high levels of resistance to pyrethroid insecticides in Anopheles gambiae from Libreville, Gabon. Med Vet Entomol. 2006 Mar;20(1):27-32. Point mutations in the voltage-gated sodium channel gene involved in knockdown resistance to DDT and pyrethroid insecticides have been described in several insect species. |
1(0,0,0,1) | Details |
| 17896620 | Awolola TS, Oduola AO, Oyewole IO, Obansa JB, Amajoh CN, Koekemoer LL, Coetzee M: Dynamics of knockdown pyrethroid insecticide resistance alleles in a field population of Anopheles gambiae s.s. in southwestern Nigeria. J Vector Borne Dis. 2007 Sep;44(3):181-8. BACKGROUND & OBJECTIVES: Pyrethroid insecticide resistance in the malaria vector Anopheles gambiae Giles is mainly associated with reduced target site sensitivity arising from a single point mutation in the sodium channel gene, often referred to as knockdown resistance (kdr). |
1(0,0,0,1) | Details |
| 18043750 | Pinto J, Lynd A, Vicente JL, Santolamazza F, Randle NP, Gentile G, Moreno M, Simard F, Charlwood JD, do Rosario VE, Caccone A, Della Torre A, Donnelly MJ: Multiple origins of knockdown resistance mutations in the Afrotropical mosquito vector Anopheles gambiae. PLoS One. 2007 Nov 28;2(11):e1243. In the malaria vector Anopheles gambiae two point mutations (L1014F and L1014S) in the voltage-gated sodium channel gene, that confer knockdown resistance (kdr) to DDT and pyrethroid insecticides, have been described. |
1(0,0,0,1) | Details |
| 18405930 | Okoye PN, Brooke BD, Koekemoer LL, Hunt RH, Coetzee M: Characterisation of DDT, pyrethroid and resistance in Anopheles funestus from Obuasi, Ghana. Trans R Soc Trop Med Hyg. 2008 Jun;102(6):591-8. Epub 2008 Apr 10. The sodium channel gene of DDT survivors and DDT-susceptible individuals was PCR amplified and sequenced to determine whether any kdr-type mutations were present. |
1(0,0,0,1) | Details |
| 16820067 | Kulkarni MA, Rowland M, Alifrangis M, Mosha FW, Matowo J, Malima R, Peter J, Kweka E, Lyimo I, Magesa S, Salanti A, Rau ME, Drakeley C: Occurrence of the -to- knockdown resistance (kdr) mutation in Anopheles arabiensis populations in Tanzania, detected by a simplified high-throughput SSOP-ELISA method. Malar J. 2006 Jul 5;5:56. Knockdown resistance (kdr) confers resistance to the pyrethroid class of insecticides with cross-resistance to DDT through single nucleotide polymorphisms (SNPs) in the voltage-gated sodium channel gene. |
1(0,0,0,1) | Details |
| 16007969 | Yaicharoen R, Kiatfuengfoo R, Chareonviriyaphap T, Rongnoparut P: Characterization of deltamethrin resistance in field populations of Aedes aegypti in Thailand. J Vector Ecol. 2005 Jun;30(1):144-50. The partial cDNA sequence of the para-type voltage-dependent sodium channel (IIS4-IIS6) was determined for BKH and PSC populations. |
1(0,0,0,1) | Details |
| 19190219 | Kazanidou A, Nikou D, Grigoriou M, Vontas J, Skavdis G: Short report: a multiplex PCR assay for simultaneous genotyping of kdr and ace-1 loci in Anopheles gambiae. Am J Trop Med Hyg. 2009 Feb;80(2):236-8. Here we describe a novel multiplex polymerase chain reaction-based assay for detecting simultaneously the five single nucleotide polymorphisms in the voltage-gated sodium channel and the ace-1 genes, which have been associated with the mosquito response to most commonly used insecticides. |
1(0,0,0,1) | Details |
| 18312471 | Wondji CS, Priyanka De Silva WA, Hemingway J, Ranson H, Parakrama Karunaratne SH: Characterization of knockdown resistance in DDT- and pyrethroid-resistant Culex quinquefasciatus populations from Sri Lanka. Trop Med Int Health. 2008 Apr;13(4):548-55. Epub 2008 Feb 26. We report the presence of two mutant alleles of the sodium channel gene, the target site for both DDT and pyrethroid insecticides. |
1(0,0,0,1) | Details |
| 19769039 | Djadid ND, Jazayeri H, Gholizadeh S, Rad ShP, Zakeri S: First record of a new member of Anopheles Hyrcanus Group from Iran: molecular identification, diagnosis, phylogeny, status of kdr resistance and Plasmodium infection. J Med Entomol. 2009 Sep;46(5):1084-93. Furthermore, we identified and compared partial sequences of exons I and II and the whole intron I region of insecticide resistance-related voltage-gated sodium channel (vgsc) gene in populations of Hyrcanus Group and other main old world Anopheles species. |
1(0,0,0,1) | Details |
| 18402139 | Janeira F, Vicente JL, Kanganje Y, Moreno M, Do Rosario VE, Cravo P, Pinto J: A primer-introduced restriction analysis-polymerase chain reaction method to detect knockdown resistance mutations in Anopheles gambiae. J Med Entomol. 2008 Mar;45(2):237-41. In the major malaria vector Anopheles gambiae Giles, two point mutations at the voltage-gated sodium channel have been associated with knockdown resistance (kdr) to DDT and pyrethroid insecticides. |
1(0,0,0,1) | Details |
| 18445265 | Santolamazza F, Calzetta M, Etang J, Barrese E, Dia I, Caccone A, Donnelly MJ, Petrarca V, Simard F, Pinto J, della Torre A: Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa. Malar J. 2008 Apr 29;7:74. BACKGROUND: Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium channel gene, resulting in either a - (L1014F), or a -serine (L1014S) substitution. |
1(0,0,0,1) | Details |
| 18051777 | Djadid ND, Forouzesh F, Karimi M, Raeisi A, Hassan-Zehi A, Zakeri S: Monitoring pyrethroid insecticide resistance in major malaria vector Anopheles culicifacies: comparison of molecular tools and conventional susceptibility test. Iran Biomed J. 2007 Jul;11(3):169-76. METHODS: In current study, along with WHO routine susceptibility test with DDT (4%), dieldrin (0.4%), malathion (5%), permethrin (0.25%), lambadacyhalothrin (0.1%), and deltamethrin 0.025, we cloned and sequenced segment VI of domain II (SII6) in voltage-gated sodium channel (vgsc) gene of An. culicifacies specimens collected in Sistan and Baluchistan province (Iran). |
1(0,0,0,1) | Details |
| 18817564 | Dabire KR, Diabate A, Djogbenou L, Ouari A, N'Guessan R, Ouedraogo JB, Hougard JM, Chandre F, Baldet T: Dynamics of multiple insecticide resistance in the malaria vector Anopheles gambiae in a rice growing area in South-Western Burkina Faso. Malar J. 2008 Sep 25;7:188. Cross-resistance to DDT and pyrethroids was conferred by alterations at site of action in the sodium channel, the - kdr mutation; resistance to organophosphates and carbamates resulted from a single point mutation in the oxyanion hole of the acetylcholinesterase enzyme designed as ace-1R. |
1(0,0,0,1) | Details |
| 15210997 | Stump AD, Atieli FK, Vulule JM, Besansky NJ: Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles gambiae in response to insecticide-treated bed net trials. Am J Trop Med Hyg. 2004 Jun;70(6):591-6. Permethrin and DDT resistance in Anopheles gambiae s.s. associated with a -serine knockdown resistance (kdr) mutation in the voltage-gated sodium channel gene was discovered recently in western Kenya where a large scale permethrin-impregnated bed net (ITN) program has been implemented. |
1(0,0,0,1) | Details |
| 15476966 | Foil LD, Coleman P, Eisler M, Fragoso-Sanchez H, Garcia-Vazquez Z, Guerrero FD, Jonsson NN, Langstaff IG, Li AY, Machila N, Miller RJ, Morton J, Pruett JH, Torr S: Factors that influence the prevalence of acaricide resistance and tick-borne diseases. Vet Parasitol. 2004 Oct 28;125(1-2):163-81. A PCR-based assay to detect a specific sodium channel gene mutation that is associated with resistance to permethrin has been developed. |
1(0,0,0,1) | Details |
| 16263118 | Usherwood PN, Vais H, Khambay BP, Davies TG, Williamson MS: Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4-S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin. FEBS Lett. 2005 Nov 21;579(28):6317-25. Epub 2005 Oct 21. |
0(0,0,0,0) | Details |