Protein Information

Name cytochrome b
Synonyms COB; CYTB; Cytochrome b; Cytochrome b of complex III; MT CYB; MTCYB; mitochondrially encoded cytochrome b; Cytochrome bs…

Compound Information

Name bifenazate
CAS 1-methylethyl 2-(4-methoxy[1,1′-biphenyl]-3-yl)hydrazinecarboxylate

Reference List

PubMed Abstract RScore(About this table)
19165831 Van Nieuwenhuyse P, Van Leeuwen T, Khajehali J, Vanholme B, Tirry L: Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl. Pest Manag Sci. 2009 Apr;65(4):404-12.

BACKGROUND: Resistance of Tetranychus urticae Koch to bifenazate was recently linked with mutations in the mitochondrial cytochrome b Q (o) pocket, suggesting that bifenazate acts as a Q (o) inhibitor (Q (o) I).
93(1,1,3,3) Details
18408150 Van Leeuwen T, Vanholme B, Van Pottelberge S, Van Nieuwenhuyse P, Nauen R, Tirry L, Denholm I: Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in action. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):5980-5. Epub 2008 Apr 11.

They also provide strong evidence of cytochrome b being the target site for bifenazate in spider mites.
87(1,1,2,2) Details
19771398 Stavrinides MC, Van Nieuwenhuyse P, Van Leeuwen T, Mills NJ: Development of acaricide resistance in Pacific spider mite (Tetranychus pacificus) from California vineyards. Exp Appl Acarol. 2010 Mar;50(3):243-54. Epub 2009 Sep 22.

In addition, we sequenced part of the cytochrome b gene of bifenazate-resistant and -susceptible T. pacificus to test for the presence of mutations reported to confer resistance to the congeneric T. urticae.
6(0,0,1,1) Details