Protein Information

Name brains
Synonyms BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA…

Compound Information

Name chlordecone
CAS

Reference List

PubMed Abstract RScore(About this table)
6180171 Hoskins B, Ho IK: Chlordecone-induced alterations in content and subcellular distribution of calcium in mouse brain. J Toxicol Environ Health. 1982 Apr;9(4):535-44.

Acute exposure to chlordecone (no signs of neurotoxicity) increased significantly total brain, protein-bound, nuclear, mitochondrial, and myelin Ca in brains from young mice.
113(1,2,2,3) Details
6186959 Fujimori K, Nabeshima T, Ho IK, Mehendale HM: Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice. Neurotoxicology. 1982 Oct;3(2):143-8.

Levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the 5-HT metabolite, 5-hydroxyindole acetic acid (5-HIAA) were determined in brains of mice after daily oral administration of 10, 25 or 50 mg/kg of chlordecone or mirex until mortality occurred.
31(0,1,1,1) Details
2471839 Jinna RR, Uzodinma JE, Desaiah D: Age-related changes in rat brain ATPases during treatment with chlordecone. J Toxicol Environ Health. 1989;27(2):199-208.

Both these enzymes were more sensitive to chlordecone in the neonatal brains as compared to adult rats (20-50 d).
6(0,0,1,1) Details
2581194 Cooper JR, Vodicnik MJ, Gordon JH: Effects of perinatal Kepone exposure on sexual differentiation of the rat brain. Neurotoxicology. 1985 Spring;6(1):183-90.


At 120 days of age, animals were sacrificed and the brains were examined histologically and the volume of the medial preoptic nucleus was determined.
1(0,0,0,1) Details
3599087 Leach JF, Charles AK: Regional mirex distribution and its effects on gamma-aminobutyric acid and flunitrazepam binding in mouse brains. J Toxicol Environ Health. 1987;21(4):423-33.

Unlike the major effects of chlordecone (an analog of mirex) on the dopaminergic system, mirex seems to be primarily neurotoxic through its more specific interaction with the GABA and FNZ binding sites.
1(0,0,0,1) Details