Protein Information

Name alpha2 adrenoceptors (protein family or complex)
Synonyms Alpha adrenoceptor; Alpha adrenoceptor; Alpha adrenergic receptor; Alpha adrenergic receptors; Alpha adrenoceptors; Alpha adrenoceptors; alpha1 Adrenoceptors; alpha1 Adrenoceptor…

Compound Information

Name chlordimeform
CAS

Reference List

PubMed Abstract RScore(About this table)
1658985 Stoker TE, Goldman JM, Cooper RL, McElroy WK: Influence of chlordimeform on alpha-adrenergic receptor-associated mechanisms of hormonal regulation in the rat: pituitary and adrenocortical secretion. Toxicology. 1991;69(3):257-68.

The acaricide chlordimeform (CDF) has been reported to have effects on the central nervous system that appear to involve an interaction with alpha-adrenergic receptor-mediated mechanisms of neurotransmission.
113(1,2,2,3) Details
2113720 Goldman JM, Cooper RL, Laws SC, Rehnberg GL, Edwards TL, McElroy WK, Hein JF: Chlordimeform-induced alterations in endocrine regulation within the male rat reproductive system. Toxicol Appl Pharmacol. 1990 Jun 1;104(1):25-35.

The acaricide chlordimeform has been reported to have adverse effects in mammals that may be mediated by an interaction with alpha-adrenergic receptors.
81(1,1,1,1) Details
2552275 Costa LG, Wu DS, Olibet G, Murphy SD: Formamidine pesticides and alpha 2-adrenoceptors: studies with amitraz and chlordimeform in rats and development of a radioreceptor binding assay. Neurotoxicol Teratol. 1989 Jul-Aug;11(4):405-11.

The interaction of the formamidine pesticides chlordimeform (CDM) and amitraz (AMZ) with rat brain alpha2-adrenoceptors was investigated.
31(0,1,1,1) Details
11312645 Altobelli D, Martire M, Maurizi S, Preziosi P: Interaction of formamidine pesticides with the presynaptic alpha (2)-adrenoceptor regulating. Toxicol Appl Pharmacol. 2001 May 1;172(3):179-85.

The effects of the formamidine pesticides amitraz and chlordimeform on the alpha (2)-adrenergic receptor subtype that mediates the release of [(3) H] noradrenaline by synaptosomes from rat hypothalami were studied.
31(0,1,1,1) Details
2832971 Boyes WK, Moser VC: An alpha 2-adrenergic mode of action of chlordimeform on rat visual function. Toxicol Appl Pharmacol. 1988 Mar 15;92(3):402-18.

The hypothesis that chlordimeform increased the amplitude of components N1P1 and P1N3 in rat pattern-reversal visual evoked potentials through actions on alpha 2-adrenergic receptors was tested with two sets of experiments.
6(0,0,1,1) Details
7712020 Roeder T: Pharmacology of the octopamine receptor from locust central nervous tissue (OAR3). Br J Pharmacol. 1995 Jan;114(1):210-6.

Some PIIs had a more than 30 times higher affinity for OARs than for alpha-adrenoceptors which are the vertebrate homologues of the insect octopamine receptors. 5.
A variety of substances with known insecticidal activity such as chlordimeform, demethylchlor-dimeform, amitraz or AC 6 had high affinity for the locust neuronal octopamine receptor.
1(0,0,0,1) Details
3034195 Costa LG, Murphy SD: Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study. Arch Toxicol. 1987 Feb;59(5):323-7.

These results show that CDM and its metabolite DCDM can interact directly in vitro with alpha-adrenergic receptors, suggesting that these receptors could mediate some of the effects of CDM and DCDM in vivo.
1(0,0,0,1) Details