| Name | alpha adrenoceptor |
|---|---|
| Synonyms | Alpha 2A Adrenoceptor; ZNF32; ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; Alpha 2A adrenergic receptor… |
| Name | chlordimeform |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2508150 | Gilbert ME, Mack CM: Enhanced susceptibility to kindling by chlordimeform may be mediated by a local anesthetic action. Psychopharmacology. 1989;99(2):163-7. Male rats were administered 0, 10 and 40 mg/kg of the local anesthetic lidocaine, 0, 0.01 and 0.10 mg/kg of the alpha-2 adrenergic agonist clonidine or 0, 10 and 30 mg/kg chlordimeform, IP, once per day. |
82(1,1,1,2) | Details |
| 2832971 | Boyes WK, Moser VC: An alpha 2-adrenergic mode of action of chlordimeform on rat visual function. Toxicol Appl Pharmacol. 1988 Mar 15;92(3):402-18. |
63(0,2,2,3) | Details |
| 6326347 | Hsu WH, Kakuk TJ: Effect of amitraz and chlordimeform on heart rate and pupil diameter in rats: mediated by alpha 2-adrenoreceptors. Toxicol Appl Pharmacol. 1984 May;73(3):411-5. Pupillary and cardiac responses to the insecticide/acaricide amitraz (0.03 to 1.0 mg/kg, iv) and chlordimeform (0.03 to 10.0 mg/kg, iv), as well as the alpha 2-adrenergic agonists clonidine (1 to 30 micrograms/kg, iv) and xylazine (10 to 300 micrograms/kg, iv), were investigated in rats anesthetized with an ether and pentobarbital combination. |
32(0,1,1,2) | Details |
| 2163971 | Wu D, Costa LG, Murphy SD: [The effect of pesticides-CDM and AMZ on inhibition of the binding of 3H-clonidine to alpha 2-adrenoreceptor in rat forebrain tissue]. Hua Xi Yi Ke Da Xue Xue Bao. 1990 Mar;21(1):17-21. Chlordimeform (CDM) and Amitraz (AMZ) are two formamidine pesticides. |
2(0,0,0,2) | Details |
| 3211100 | Gilbert ME: Formamidine pesticides enhance susceptibility to kindled seizures in amygdala and hippocampus of the rat. Neurotoxicol Teratol. 1988 May-Jun;10(3):221-7. Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. The alpha-2 adrenergic agonist and/or local anesthetic-like properties of these compounds may be responsible for these seizure enhancing effects. |
1(0,0,0,1) | Details |
| 2849009 | Hsu WH, Smith BE, Hollingworth RM: The bradycardic and mydriatic effects of chlordimeform and its demethylated analogs in the rat: antagonism by idazoxan but not by prazosin. Life Sci. 1988;43(23):1897-904. The results suggested: 1) the mydriatic and bradycardic effects of CDM and DCDM are mediated by alpha 2-adrenoreceptors, 2) the monodemethylation of CDM increases its alpha 2-adrenoreceptor agonistic activities, but the didemethylation of CDM abolishes these activities, and 3) CDM can exert alpha 2-adrenoreceptor agonistic activities without undergoing a demethylation process. |
1(0,0,0,1) | Details |
| 11312645 | Altobelli D, Martire M, Maurizi S, Preziosi P: Interaction of formamidine pesticides with the presynaptic alpha (2)-adrenoceptor regulating. Toxicol Appl Pharmacol. 2001 May 1;172(3):179-85. The effects of the formamidine pesticides amitraz and chlordimeform on the alpha (2)-adrenergic receptor subtype that mediates the release of [(3) H] by synaptosomes from rat hypothalami were studied. Amitraz also diminished the inhibitory effects of the alpha (2)-adrenergic agonists clonidine and xylazine. |
1(0,0,0,1) | Details |
| 15703397 | Stevenson PA, Dyakonova V, Rillich J, Schildberger K: and experience-dependent modulation of aggression in crickets. J Neurosci. 2005 Feb 9;25(6):1431-41. Hemocoel injections of the agonist chlordimeform (CDM) had similar effects on aggression but also enhanced startle responses. |
0(0,0,0,0) | Details |