| Name | prothrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | chlorophacinone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3222685 | Vogel JJ, de Moerloose P, Bouvier CA, Gaspoz J, Riant P: [Prolonged anticoagulation following chlorophacinone poisoning] . Schweiz Med Wochenschr. 1988 Dec 17;118(50):1915-7. In a search for a relation between the variations of prothrombin time and chlorophacinone plasma levels, these were assessed by HPLC. |
13(0,0,2,3) | Details |
| 19752778 | Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50. RESULTS AND CONCLUSION: In this manuscript we report the prothrombin times measured in the F7 generation after exposure to chlorophacinone, bromadiolone, difenacoum and difethialone. |
6(0,0,1,1) | Details |
| 3704331 | Shlosberg A, Egyed MN: Stability of prothrombin times in sheep dosed with natural and synthetic anticoagulants. Res Vet Sci. 1986 Mar;40(2):141-3. |
2(0,0,0,2) | Details |
| 2729812 | Chataigner D, Garnier R, Elmalem J, Efthymiou ML: [Prolonged hypocoagulability following the ingestion of anticoagulant raticides]. Ann Med Interne. 1989;139(8):537-41. The products implicated were chlorophacinone, bromadiolone, and The prothrombin time varied with the administered dose of and/or coagulation factors. |
2(0,0,0,2) | Details |
| 4078974 | Blus LJ, Henny CJ, Grove RA: Effects of pelletized anticoagulant rodenticides on California quail. J Wildl Dis. 1985 Oct;21(4):391-5. Pellets containing the anticoagulant chlorophacinone (Rozol, RO) were in the crop; the gizzard contents consisted of a pink mass of paraffin that was selectively accumulated from the paraffinized pellets. The plasma prothrombin time of 28 sec was near that determined for control quail. |
1(0,0,0,1) | Details |
| 16454646 | Berny PJ, de Oliveira LA, Videmann B, Rossi S: Assessment of ruminal degradation, oral bioavailability, and toxic effects of anticoagulant rodenticides in sheep. Am J Vet Res. 2006 Feb;67(2):363-71. OBJECTIVE: To assess the rate and extent of ruminal degradation of chlorophacinone, and bromadiolone in vitro and determine the oral availability and clinical and hemostatic effects of each anticoagulant rodenticide in adult sheep. At intervals during a 240- to 360- hour period after treatment, prothrombin time (PT) was measured, plasma anticoagulant concentration was assessed, and clinical signs of rodenticide poisoning were monitored. |
1(0,0,0,1) | Details |
| 16506805 | Lawley WJ, Charlton AJ, Hughson EJ, Grundy HH, Brown PM, Jones A: Development of a cell culture/ELISA assay to detect anticoagulant rodenticides and its application to analysis of rodenticide treated grain. J Agric Food Chem. 2006 Mar 8;54(5):1588-93. This study describes a generic biological screening assay designed to detect anticoagulant rodenticides based on their inhibitory action on the vitamin K epoxide reductase protein complex, resulting in an accumulation of under-carboxylated prothrombin or proteins induced by antagonism (PIVKA-II). |
1(0,0,0,1) | Details |
| 10216974 | Lagrange F, Corniot AG, Titier K, Bedry R, Pehourcq F: Toxicological management of chlorophacinone poisoning. Acta Clin Belg Suppl. 1999;1:13-6. The examination revealed excitation and nausea, with a normal prothrombin index (PI). |
1(0,0,0,1) | Details |
| 17384395 | Binks S, Davies P: Case of the month: "Oh! Drat!--A case of transcutaneous superwarfarin poisoning and its recurrent presentation". Emerg Med J. 2007 Apr;24(4):307-8. The original inpatient team had not identified the specific poison (chlorophacinone). He had grossly deranged clotting studies (prothrombin time (PT) > 200 s, activated partial thromboplastin time (APTT) 56 s) that were rapidly corrected with fresh frozen plasma and |
1(0,0,0,1) | Details |
| 16499407 | Watt BE, Proudfoot AT, Bradberry SM, Vale JA: Anticoagulant rodenticides. Toxicol Rev. 2005;24(4):259-69. This group includes the second generation 4-hydroxycoumarins brodifacoum, bromadiolone, difenacoum, flocoumafen and the indanedione derivatives chlorophacinone and diphacinone. |
0(0,0,0,0) | Details |