| Name | cytochrome P450 side chain cleavage enzyme |
|---|---|
| Synonyms | CYP11A; CYP11A1; CYPXIA 1; CYPXIA1; Cholesterol 20 22 desmolase; Cholesterol desmolase; Cholesterol monooxygenase (side chain cleaving); Cholesterol side chain cleavage enzyme… |
| Name | fenvalerate |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15907653 | Chen J, Chen H, Liu R, He J, Song L, Bian Q, Xu L, Zhou J, Xiao H, Dai G, Chang HC, Wang X: Effects of fenvalerate on production in cultured rat granulosa cells. Reprod Toxicol. 2005 Jul-Aug;20(2):195-202. Fenvalerate reduced mRNA and protein expression of P450scc. |
163(2,2,2,3) | Details |
| 18053657 | Qu JH, Hong X, Chen JF, Wang YB, Sun H, Xu XL, Song L, Wang SL, Wang XR: Fenvalerate inhibits production through cAMP-dependent signal pathway. Toxicol Lett. 2008 Jan 4;176(1):31-9. Epub 2007 Sep 21. In addition, fenvalerate decreased steroidogenic acute regulatory protein (StAR) mRNA and protein levels, and also profoundly inhibited the activity of P450 side chain cleavage enzyme (P450scc) which was consistent with the decreased expression of P450scc mRNA and protein in MLTC-1 cells. |
162(2,2,2,2) | Details |
| 19683566 | Zhang H, Wang H, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Zhao XF, Wang Q, Liu P, Meng XH, Xu DX: Lactational fenvalerate exposure permanently impairs testicular development and spermatogenesis in mice. Toxicol Lett. 2009 Dec 1;191(1):47-56. Epub 2009 Aug 14. Additional experiment showed that lactational fenvalerate exposure markedly reduced mRNA and protein levels of testicular P450scc, a (T) synthesis enzyme. |
88(1,1,2,3) | Details |
| 19892000 | Fei J, Qu JH, Ding XL, Xue K, Lu CC, Chen JF, Song L, Xia YK, Wang SL, Wang XR: Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles. Toxicology. 2010 Jan 12;267(1-3):1-6. Epub 2009 Nov 3. These results suggested that fenvalerate restrained the follicular growth, and inhibited steroidogenesis by reducing StAR and P450scc gene expression, which might further contribute to the fenvalerate-induced reproductive dysfunction. |
83(1,1,1,3) | Details |
| 20063364 | Zhang H, Wang H, Wang Q, Zhao XF, Liu P, Ji YL, Ning H, Yu T, Zhang C, Zhang Y, Meng XH, Xu DX: Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood. J Appl Toxicol. 2010 Jan 8. Although pubertal and early adult exposure to fenvalerate had little effect on the number of Leydig cells in testes, mRNA and protein levels of testicular T biosynthetic enzymes including P450 (17alpha) and P450scc were significantly downregulated in fenvalerate-treated mice. |
6(0,0,1,1) | Details |
| 16001830 | Chen JF, Chen HY, Liu R, He J, Song L, Bian Q, Xu LC, Zhou JW, Xiao H, Dai GD, Wang XR: Effects of fenvalerate on steroidogenesis in cultured rat granulosa cells. Biomed Environ Sci. 2005 Apr;18(2):108-16. |
0(0,0,0,0) | Details |