Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name fenvalerate
CAS cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
12858966 Kamalaveni K, Gopal V, Sampson U, Aruna D: Recycling and utilization of metabolic wastes for energy production is an index of biochemical adaptation of fish under environmental pollution stress. Environ Monit Assess. 2003 Aug;86(3):255-64.

The activity levels of lactate dehydrogenase and lactic acid were assessed in various tissues of the fish during exposure to lethal concentration of group-II Pyrethroids (deltamethrin, cypermethrin, fenvalerate and fluvalinate) for a period of 72 hours.
7(0,0,1,2) Details
1859437 Reddy AT, Yellamma K: The possible metabolic diversions adapted by the cockroach, Periplaneta americana to counteract the toxicity of fenvalerate. Biochem Int. 1991 Jan;23(2):359-65.

Lactate content and lactate dehydrogenase (LDH) activity also showed an elevation following fenvalerate toxicity.
6(0,0,1,1) Details
2311558 Radhaiah V, Rao KJ: Toxicity of the pyrethroid insecticide fenvalerate to a fresh water fish, Tilapia mossambica (Peters): changes in glycogen metabolism of muscle. Ecotoxicol Environ Saf. 1990 Feb;19(1):116-21.

The changes included a significant (P less than 0.001) decrease in the levels of glycogen, pyruvate, maleate dehydrogenase (MDH), succinate dehydrogenase (SDH), and phosphorylase a, b, and ab activities, while elevated levels of lactic acid, aldolase, and lactate dehydrogenase (LDH) activity were observed under fenvalerate intoxication.
6(0,0,1,1) Details
15313449 Tripathi G, Verma P: Fenvalerate-induced changes in a catfish, Clarias batrachus: metabolic enzymes, RNA and protein. Comp Biochem Physiol C Toxicol Pharmacol. 2004 May;138(1):75-9.

Exposure to fenvalerate gradually decreased the activity of citrate synthase (CS), glucose 6-phosphate dehydrogenase (G6-PDH) and lactate dehydrogenase (LDH) in brain, liver and skeletal muscle up to 21 days.
6(0,0,1,1) Details
15803954 Mushigeri SB, David M: Accumulation of fenvalerate and related changes in lactate and succinate dehydrogenases activity in functionally different tissues of the freshwater fish, Cirrhinus mrigala (Hamilton). J Basic Clin Physiol Pharmacol. 2004;15(3-4):143-52.

Enzyme assay indicated an increased activity of lactate dehydrogenase, whereas the activity of succinate dehydrogenase decreased continuously up to 96 h in all selected tissues.
1(0,0,0,1) Details
11862614 Mani U, Islam F, Prasad AK, Kumar P, Maji BK, Dutta KK: Pulmonary toxicity of a formulated preparation of fenvalerate in rats subchronically exposed by nose only inhalation for 90 days. Biomed Environ Sci. 2001 Dec;14(4):333-40.

RESULTS: Fen exposed rats showed a significant increase in enzymatic activities of lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and gamma-glutamyl transferase (gamma-GT) which are considered as biochemical indicators of pulmonary damage.
1(0,0,0,1) Details