Protein Information

Name cAMP dependent protein kinase (protein family or complex)
Synonyms Protein kinase A; cAMP dependent protein kinase; cAMP dependent protein kinases

Compound Information

Name fenvalerate
CAS cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
15907653 Chen J, Chen H, Liu R, He J, Song L, Bian Q, Xu L, Zhou J, Xiao H, Dai G, Chang HC, Wang X: Effects of fenvalerate on progesterone production in cultured rat granulosa cells. Reprod Toxicol. 2005 Jul-Aug;20(2):195-202.

These results suggested that multi-site inhibition of progesterone production by fenvalerate including a cAMP-dependent protein kinase pathway and reduction on P450scc gene expression and/or its enzymatic activity in rGCs.
31(0,1,1,1) Details
9271338 Enz A, Pombo-Villar E: Class II pyrethroids: noninhibitors calcineurin. . Biochem Pharmacol. 1997 Jul 15;54(2):321-3.


In concentrations up to 10 (-5) M, none of the pyrethroid insecticides used in this study caused inhibition of the calcineurin-dependent dephosphorylation of the 19-amino acid phosphopeptide derived from the regulatory subunit R-II of the cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase, which has been established as a good substrate for this enzyme.
1(0,0,0,1) Details
9655866 Huang RQ, Dillon GH: Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin. J Pharmacol Exp Ther. 1998 Jul;286(1):243-55.


Inhibition of the Ca++/calmodulin-dependent phosphatase calcineurin with fenvalerate also prevented rundown of the response to GABA.
0(0,0,0,0) Details