| Name | calcineurin (protein family or complex) |
|---|---|
| Synonyms | Calcineurin; Calcineurins; Protein phosphatase 2B |
| Name | fenvalerate |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1315545 | Enan E, Matsumura F: Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. |
85(1,1,1,5) | Details |
| 9714322 | Fakata KL, Swanson SA, Vorce RL, Stemmer PM: Pyrethroid insecticides as phosphatase inhibitors. . Biochem Pharmacol. 1998 Jun 15;55(12):2017-22. The type II pyrethroid insecticides cis-cypermethrin (c-Cyp), trans-cypermethrin, deltamethrin (Delt), and fenvalerate A alpha (Fen), as well as the type I pyrethroid insecticides cis- and trans-permethrin and S-bioallethrin, were unable to inhibit the phosphatase activity of purified calcineurin under conditions of maximal activation by Ca2+ and calmodulin. |
82(1,1,1,2) | Details |
| 9655866 | Huang RQ, Dillon GH: Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein phosphorylation and calcineurin. J Pharmacol Exp Ther. 1998 Jul;286(1):243-55. Inhibition of the Ca++/calmodulin-dependent phosphatase calcineurin with fenvalerate also prevented rundown of the response to |
33(0,1,1,3) | Details |
| 7531976 | Richter A, Davies DE, Alexander P: Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. Biochem Pharmacol. 1995 Jan 31;49(3):367-73. The role of calcineurin in CyA- or FK506-induced growth inhibition was investigated using the synthetic pyrethroid insecticides: cypermethrin, deltamethrin and fenvalerate, which are known calcineurin inhibitors. |
32(0,1,1,2) | Details |
| 9587652 | Lippe C, Bellantuono V, Quaranta A, Castronuovo G, Cassano G, Ardizzone C: Cyclosporin A stimulates Na+ transport across the isolated skin of Rana esculenta. Arch Physiol Biochem. 1997 Oct;105(6):596-602. The Cs A effect on Na+ transport could be caused by an inhibition of a Ca2+/calmodulin-dependent protein phosphatase, i.e. calcineurin, since: a) it is mimicked by another inhibitor of calcineurin, i.e. fenvalerate: b) the action of Cs A and fenvalerate on SCC are decreased by the calmodulin inhibitor W7. |
31(0,1,1,1) | Details |
| 9271338 | Enz A, Pombo-Villar E: Class II pyrethroids: noninhibitors calcineurin. . Biochem Pharmacol. 1997 Jul 15;54(2):321-3. |
4(0,0,0,4) | Details |
| 9070464 | Victor RG, Rusnak F, Sikkink R, Marban E, O'Rourke B: Mechanism of Ca (2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin. J Membr Biol. 1997 Mar 1;156(1):53-61. Similarly, blocking calmodulin activation with calmidazolium or blocking calcineurin with fenvalerate did not influence the extent of Ca (2+)-dependent inactivation after photolysis. |
3(0,0,0,3) | Details |
| 17200551 | Swingle M, Ni L, Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol. 2007;365:23-38. Inhibitors of PP2B (calcineurin) will only be mentioned in passing, except to state that, in our hands, cypermethrin, deltamethrin, and fenvalerate, which are sold as potent inhibitors of PP2B, do not inhibit the catalytic activity of PP2B. |
0(0,0,0,0) | Details |