Protein Information

Name protein kinase C (protein family or complex)
Synonyms Protein kinase C; PKC

Compound Information

Name fenvalerate
CAS cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
11488435 Kamei J, Sasaki M, Zushida K, Morita K, Tanaka S: Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate. Jpn J Pharmacol. 2001 Jul;86(3):336-41.

Calphostin C (3 pmol, i.t.), a protein kinase C inhibitor, inhibited fenvalerate-induced behavior.
62(0,2,2,2) Details
12383951 Kamei J, Iguchi E, Sasaki M, Zushida K, Morita K, Tanaka S: Modification of the fenvalerate-induced nociceptive response in mice by diabetes. Brain Res. 2002 Sep 6;948(1-2):17-23.

Calphostin C (3 pmol, i.t.), a selective protein kinase C inhibitor, significantly inhibited intrathecal fenvalerate-induced nociceptive behavior with a rightward shift of the dose-response curve for fenvalerate-induced nociceptive behavior to the level those observed in non-diabetic mice.
62(0,2,2,2) Details
9655866 Huang RQ, Dillon GH: Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin. J Pharmacol Exp Ther. 1998 Jul;286(1):243-55.


Inhibition of the Ca++/calmodulin-dependent phosphatase calcineurin with fenvalerate also prevented rundown of the response to GABA.
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