| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | fenarimol |
|---|---|
| CAS | α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8485514 | Grieneisen ML, Warren JT, Gilbert LI: Early steps in ecdysteroid biosynthesis: evidence for the involvement of cytochrome P-450 enzymes. Insect Biochem Mol Biol. 1993 Jan;23(1):13-23. The first step in the biosynthesis of ecdysteroids by Manduca sexta prothoracic glands, the conversion of to is mediated by an enzyme with characteristics of a microsomal cytochrome P-450, i.e. sensitivity to CO and fenarimol, and a requirement for |
32(0,1,1,2) | Details |
| 17686559 | Canistro D, Pozzetti L, Sapone A, Broccoli M, Affatato AA, Stradiotti A, Longo V, Menichini P, Barale R, Paolini M: Perturbation of murine liver cyp-superfamily of isoforms by different combinations of pesticide mixtures. Food Chem Toxicol. 2008 Jan;46(1):34-42. Epub 2007 Jun 28. It was previously found that fenarimol, vinclozolin or acephate, three of the most used pesticides worldwide, provoked a marked perturbation of murine cytochrome P450 (CYP)-linked monooxygenases. |
31(0,1,1,1) | Details |
| 10775427 | Williams DR, Fisher MJ, Rees HH: Characterization of ecdysteroid 26-hydroxylase: an enzyme involved in molting hormone inactivation. Arch Biochem Biophys. 2000 Apr 15;376(2):389-98. Demonstration that activity of the mitochondrial 26-hydroxylase was inhibited by incubation in a CO (or N (2)) atmosphere, taken together with the requirement for reducing cofactor and the efficacy of the P450 inhibitors, ketoconazole and fenarimol, provided strong evidence that the hydroxylase is cytochrome P450-dependent. |
31(0,1,1,1) | Details |
| 2387028 | Flodstrom S, Hemming H, Warngard L, Ahlborg UG: Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis. 1990 Aug;11(8):1413-7. The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis (4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for their ability to inhibit gap junctional intercellular communication both in the Chinese hamster V79 metabolic co-operation assay and in the scrape-loading/dye-transfer assay in WB-F344 rat liver epithelial cells. |
1(0,0,0,1) | Details |
| 7627200 | Warren JT, Rybczynski R, Gilbert LI: Stereospecific, mechanism-based, suicide inhibition of a cytochrome P450 involved in ecdysteroid biosynthesis in the prothoracic glands of Manduca sexta. Insect Biochem Mol Biol. 1995 Jun;25(6):679-95. Indeed, alpha amino C was as active as the non-specific pyrimidyl cytochrome-P450 monooxygenase inhibitor fenarimol that shows moderate toxicity in many insect species. |
1(0,0,0,1) | Details |