| Name | cytochrome P450 monooxygenase |
|---|---|
| Synonyms | CYP M; CYP20A1; CYP20A1 protein; Cytochrome P450 family 20 subfamily A polypeptide 1; Cytochrome P450 monooxygenase; CYP20A1 proteins; Cytochrome P450 family 20 subfamily A polypeptide 1s; Cytochrome P450 monooxygenases |
| Name | fenarimol |
|---|---|
| CAS | α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7627200 | Warren JT, Rybczynski R, Gilbert LI: Stereospecific, mechanism-based, suicide inhibition of a cytochrome P450 involved in ecdysteroid biosynthesis in the prothoracic glands of Manduca sexta. Insect Biochem Mol Biol. 1995 Jun;25(6):679-95. Indeed, alpha amino C was as active as the non-specific pyrimidyl cytochrome-P450 monooxygenase inhibitor fenarimol that shows moderate toxicity in many insect species. |
32(0,1,1,2) | Details |
| 2387028 | Flodstrom S, Hemming H, Warngard L, Ahlborg UG: Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis. 1990 Aug;11(8):1413-7. The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis (4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for their ability to inhibit gap junctional intercellular communication both in the Chinese hamster V79 metabolic co-operation assay and in the scrape-loading/dye-transfer assay in WB-F344 rat liver epithelial cells. The pesticides were also studied for their ability to enhance the development of gamma-glutamyltranspeptidase-positive altered hepatic foci and induce cytochrome P450 monooxygenase isoenzymes in nitrosamine-initiated male Sprague-Dawley rats. |
1(0,0,0,1) | Details |