| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | isofenphos |
|---|---|
| CAS | 1-methylethyl 2-[[ethoxy[(1-methylethyl)amino]phosphinothioyl]oxy]benzoate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. The ratio of inhibitory powers for acetylcholinesterase and NTE represents the crucial guideline for the aetiological attribution of OP-induced peripheral neuropathy. In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates. |
1(0,0,0,1) | Details |
| 12449529 | Kasagami T, Miyamoto T, Yamamoto I: Activated transformations of organophosphorus insecticides in the case of non-AChE inhibitory oxons. Pest Manag Sci. 2002 Nov;58(11):1107-17. It is well known that isofenphos oxon is converted into the stable N-desalkyl form (H2N-P (O) <) by oxidative dealkylation to inhibit AChE. |
116(1,2,2,6) | Details |
| 2284053 | Wilson BW, Henderson JD, Kellner TP, McEuen SF, Griffis LC, Lai JC: Acetylcholinesterase and neuropathy target esterase in chickens treated with acephate. Neurotoxicology. 1990 Fall;11(3):483-91. Reports that near-lethal doses of the pesticide methamidophos (O,S-dimethyl phosphoramidothioate) caused a delayed neurotoxicity (OPIDN) in humans and that another phosphoramidate, isofenphos, caused OPIDN in the hen at high doses, prompted a study of the abilities of acephate (O,S-dimethyl acetylphosphoramidothioate) to inhibit brain acetylcholinesterase (AChE) and neuropathy target esterase (NTE) in vivo. |
86(1,1,1,6) | Details |
| 12107655 | Moretto A, Lotti M: The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Arch Toxicol. 2002 Jun;76(5-6):367-75. Epub 2002 May 16. To explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced OPIDP; (2) whereas neuropathy target esterase (NTE) is thought to be the target of OPIDP, activation of isofenphos by liver microsomes causes the formation of more potent NTE inhibitor (s) in humans than in hens; (3) in contrast to hen NTE, the sensitivity of the human enzyme to such inhibitor (s) is higher than that of acetylcholinesterase (AChE), the target of cholinergic toxicity. |
68(0,2,3,3) | Details |
| 10771584 | Nigg HN, Knaak JB: Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev Environ Contam Toxicol. 2000;163:29-111. OPs possessing carboxylesters, such as malathion and isofenphos, are hydrolyzed by the direct action of 'B'-esterases (i.e., carboxylesterase, CaE). The basic biochemical characteristics of RBC AChE and BChE were determined in the 1940s. |
6(0,0,0,6) | Details |
| 15112752 | Knaak JB, Dary CC, Power F, Thompson CB, Blancato JN: Physicochemical and biological data for the development of predictive organophosphorus pesticide QSARs and PBPK/PD models for human risk assessment. Crit Rev Toxicol. 2004 Mar-Apr;34(2):143-207. Except for work on parathion, chlorpyrifos, and isofenphos, very few modeling data were found on the 31 OPs of interest. A limited amount of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CaE) inhibition and recovery data were found in the literature on the 31 OPs. |
1(0,0,0,1) | Details |
| 1566275 | Henderson JD, Higgins RJ, Dacre JC, Wilson BW: Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen. Toxicology. 1992;72(2):117-29. Plasma acetylcholinesterase (AChE), non-specific butyrylcholinesterase (BChE) and kinase (CK) activities were measured in order to monitor whether the compounds were present at biologically active concentrations. |
1(0,0,0,1) | Details |