Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name isoproturon
CAS

Reference List

PubMed Abstract RScore(About this table)
16220362 Mosleh YY, Paris-Palacios S, Couderchet M, Biagianti-Risbourg S, Vernet G: Effects of the herbicide isoproturon on metallothioneins, growth, and antioxidative defenses in the aquatic worm Tubifex tubifex (Oligochaeta, Tubificidae). Ecotoxicology. 2005 Jul;14(5):559-71. Epub 2005 Oct 12.

In response to isoproturon, the activity of glutathione-S-transferase (max. +52%), glutathione-reductase (max. +100%), and catalase (max. +117%) increased, demonstrating the occurrence of an oxidative stress response to the herbicide.
6(0,0,1,1) Details
18522406 Yin XL, Jiang L, Song NH, Yang H: Toxic reactivity of wheat (Triticum aestivum) plants to herbicide isoproturon. J Agric Food Chem. 2008 Jun 25;56(12):4825-31. Epub 2008 Jun 4.

We also tested the activity of glutathione S-transferase (GST) and observed the activity stimulated by isoproturon at 2-10 mg/kg.
6(0,0,1,1) Details
11838280 Reade JP, Cobb AH: New, quick tests for herbicide resistance in black-grass (Alopecurus myosuroides Huds) based on increased glutathione S-transferase activity and abundance. Pest Manag Sci. 2002 Jan;58(1):26-32.

2(0,0,0,2) Details
15540603 Belford EJ, Dorfler U, Stampfl A, Schroder P: Microsomal detoxification enzymes in yam bean [Pachyrhizus erosus (L.) urban]. Z Naturforsch C. 2004 Sep-Oct;59(9-10):693-700.

Cytochrome P450s and glutathione-S-transferases (GSTs) constitute two of the largest groups of enzyme families that are responsible for detoxification of exogenous molecules in plants.
The breakdown of the herbicide isoproturon (IPU) to two distinct metabolites, 1-OH-IPU and monodesmethyl-IPU, was demonstrated.
1(0,0,0,1) Details
8402576 Hoshiya T, Hasegawa R, Hakoi K, Cui L, Ogiso T, Cabral R, Ito N: Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat. Cancer Lett. 1993 Aug 16;72(1-2):59-64.

The potential hepatocarcinogenicity of seven pesticides was examined using a rapid bioassay based on the induction of glutathione S-transferase placental form positive foci in the rat liver.
Positive results were seen with chlorobenzilate (2000 ppm), vinclozolin (2000 ppm), malathion (4000 ppm), tecnazene (2000 ppm) and isoproturon (2000 ppm).
1(0,0,0,1) Details
12297088 Greulich K, Hoque E, Pflugmacher S: Uptake, metabolism, and effects on detoxication enzymes of isoproturon in spawn and tadpoles of amphibians. Ecotoxicol Environ Saf. 2002 Jul;52(3):256-66.

In tadpoles of B. variegata, the activity of microsomal and soluble glutathione-S-transferase (sGSTs) toward different model substrates was measured after treatment with IPU.
1(0,0,0,1) Details
11464789 Cocker KM, Northcroft DS, Coleman JO, Moss SR: Resistance to ACCase-inhibiting herbicides and isoproturon in UK populations of Lolium multiflorum: mechanisms of resistance and implications for control. Pest Manag Sci. 2001 Jul;57(7):587-97.

Biochemical analyses of acetyl coenzyme A carboxylase (ACCase) activity, oxygen consumption by thylakoids, diclofop metabolism and glutathione S-transferase activity showed that, in three of the resistant populations, an enhanced rate of herbicide metabolism conferred resistance.
1(0,0,0,1) Details