Protein Information

Name cytochrome bc1
Synonyms Cytochrome bc1; D3S3191; UQCRC 1; UQCRC1; Ubiquinol cytochrome C reductase complex core protein I mitochondrial; Ubiquinol cytochrome c reductase core protein I; Ubiquinol cytochrome C reductase complex core protein I mitochondrials; Ubiquinol cytochrome c reductase core protein Is

Compound Information

Name kresoxim-methyl
CAS

Reference List

PubMed Abstract RScore(About this table)
12233180 Ziogas BN, Markoglou AN, Tzima A: A non-Mendelian inheritance of resistance to strobilurin fungicides in Ustilago maydis. Pest Manag Sci. 2002 Sep;58(9):908-16.

Cross-resistance studies with other fungicides, which also inhibit electron transport through complex III of respiratory chain, showed that mutations for resistance to azoxystrobin were also responsible for reduced sensitivity to kresoxim-methyl (RF 18 to 1199) and to antimycin-A (RF 20 to 305), which act at the Qo and Qi sites of the cytochrome bc1 complex, respectively.
32(0,1,1,2) Details
19928849 Zhao PL, Wang L, Zhu XL, Huang X, Zhan CG, Wu JW, Yang GF: Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues. J Am Chem Soc. 2010 Jan 13;132(1):185-94.

Eight new compounds were designed and synthesized, among which compound 5c, with a K (i) value of 570 pM, was identified as the most promising drug or fungicide candidate, significantly more potent than the commercially available bc (1) inhibitors, including azoxystrobin (AZ), kresoxim-methyl (KM), and pyraclostrobin (PY).
1(0,0,0,1) Details
11975172 Farber RB, Chin KM, Leadbitter N: Sensitivity of Venturia inaequalis to trifloxystrobin. Pest Manag Sci. 2002 Mar;58(3):261-7.


Data also show that trifloxystrobin is not cross-resistant to anilinopyrimidines and triazoles, but is cross-resistant to kresoxim-methyl, another strobilurin which also inhibits the cytochrome bc1 enzyme complex at the Qo-site in the respiration chain of fungal mitochondria (QoI inhibitors).
0(0,0,0,0) Details