| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | linuron |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18835618 | Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H: In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere. 2008 Dec;74(1):155-65. Epub 2008 Oct 5. |
7(0,0,1,2) | Details |
| 7823289 | Scassellati-Sforzolini G, Moretti M, Villarini M, Monarca S, Fatigoni C, Pasquini R: In vivo studies on enzymatic induction activity of Linuron. . J Environ Pathol Toxicol Oncol. 1994;13(1):11-7. The cytochrome P450-dependent monooxigenase activities of aryl hydrocarbon hydroxylase (AHH) and of aminopyrine N-demethylase (APD) were measured in rat livers after a 14-d treatment by gavage with Linuron. |
6(0,0,1,1) | Details |
| 16040568 | Hwang DY, Cho JS, Oh JH, Shim SB, Jee SW, Lee SH, Seo SJ, Kang HG, Sheen YY, Lee SH, Kim YK: An in vivo bioassay for detecting antiandrogens using humanized transgenic mice coexpressing the tetracycline-controlled transactivator and human CYP1B1 gene. Int J Toxicol. 2005 May-Jun;24(3):157-64. To evaluate its ability for detecting antiandrogens, in vivo the dose effect of di-(2-ethylhexyl) (DEHP) and time effect of five antiandrogens, DEHP, di-n-butyl (DBP), diethyl (DEP), linuron (3-(4-dichlorophenyl)-methoxy-1-methylurea), and 2,4'-DDE (1,1-dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethylene), were investigated using humanized transgenic mice coexpressing tetracycline-controlled transactivator (tTA) and the human cytochrome P450 (CYP) enzyme CYP1B1 (hCYP1B1). |
6(0,0,1,1) | Details |
| 11986682 | : NTP Technical Report on the Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene (CAS No. 14047-09-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1998 Nov;65:1-F6. 3,3',4,4'-Tetrachloroazobenzene is not commercially manufactured but is formed as an unwanted byproduct in the manufacture of 3,4-dichloroaniline and its herbicidal derivatives Propanil (R), Linuron (R), and Diuron (R). In addition to histopathology, evaluations included hematology (rats only), clinical chemistry, thyroid hormone analyses (rats only), cytochrome P (450) 1A immunohistochemical staining in the liver (rats only), and assessments of male reproductive endpoints and estrous cycle length. |
3(0,0,0,3) | Details |
| 12226498 | Didierjean L, Gondet L, Perkins R, Lau SM, Schaller H, O'Keefe DP, Werck-Reichhart D: Engineering herbicide metabolism in tobacco and Arabidopsis with CYP76B1, a cytochrome P450 enzyme from Jerusalem artichoke. Plant Physiol. 2002 Sep;130(1):179-89. Transformation with CYP76B1 conferred on tobacco and Arabidopsis a 20-fold increase in tolerance to linuron, a compound detoxified by a single dealkylation, and a 10-fold increase in tolerance to isoproturon or chlortoluron, which need successive catalytic steps for detoxification. |
2(0,0,0,2) | Details |