| Name | thyroperoxidase |
|---|---|
| Synonyms | MSA; TPO; TPO protein; TPX; Thyroid microsomal antigen; Thyroid peroxidase; Thyroid peroxidase isoform d variant; Thyroid peroxidase precursor… |
| Name | mancozeb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9681970 | Hurley PM: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect. 1998 Aug;106(8):437-45. Intrathyroidal and extrathyroidal sites of action are found: amitrole, ethylene thiourea, and mancozeb are thyroid peroxidase inhibitors; and acetochlor, clofentezine, fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene, prodiamine, pyrimethanil, and thiazopyr seem to enhance the hepatic metabolism and excretion of thyroid hormone. |
31(0,1,1,1) | Details |
| 9418944 | Kackar R, Srivastava MK, Raizada RB: Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations. J Appl Toxicol. 1997 Nov-Dec;17(6):369-75. Reduced levels of thyroid radioiodine ([125] I) uptake, serum protein-bound (PB [125] I), (T4) and reduced activity of thyroid peroxidase (TPO) have also been observed after exposure to mancozeb. |
31(0,1,1,1) | Details |
| 17651757 | Roman GC: Autism: transient in utero hypothyroxinemia related to maternal ingestion during pregnancy and to other environmental antithyroid agents. J Neurol Sci. 2007 Nov 15;262(1-2):15-26. Epub 2007 Jul 24. and daidzein from soy max) inhibit thyroperoxidase that catalyzes iodination and thyroid hormone biosynthesis. Environmental contaminants interfere with thyroid function including 60% of all herbicides, in particular 2,4-dichlorophenoxyacetic acid (2,4-D), acetochlor, aminotriazole, amitrole, bromoxynil, pendamethalin, mancozeb, and thioureas. |
2(0,0,0,2) | Details |