Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name mancozeb
CAS

Reference List

PubMed Abstract RScore(About this table)
15261450 Jarrard HE, Delaney KR, Kennedy CJ: Impacts of carbamate pesticides on olfactory neurophysiology and cholinesterase activity in coho salmon (Oncorhynchus kisutch). Aquat Toxicol. 2004 Aug 10;69(2):133-48.

All three carbamates also affected AChE activity levels in the OR and brain (BR): carbofuran exposure at 200 microg/l significantly inhibited AChE activity in the OR, and both IPBC and mancozeb significantly increased AChE activity in BR at multiple concentrations with acute localized exposure.
33(0,1,1,3) Details
10641187 Kackar R, Srivastava MK, Raizada RB: Assessment of toxicological effects of mancozeb in male rats after chronic exposure. Indian J Exp Biol. 1999 Jun;37(6):553-9.

Mancozeb has produced significant enzymatic changes in the activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE) throughout the period of study in a dose dependent manner.
6(0,0,1,1) Details
18585479 Falfushinska HI, Romanchuk LD, Stolyar OB: Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Sep;148(3):223-9. Epub 2008 Jun 8.

Laboratory studies were conducted to determine the effects of carbamate fungicide TATTU (mixture of propamocarb and mancozeb, 0.091 mg L (-1)) on biochemical markers of exposure in Rana ridibunda from clean (reference) and polluted sites.
The untreated animals from the polluted site had lower Cu,Zn- and Mn-superoxide dismutase (SOD) and acetylcholinesterase activity, the levels of lipid peroxidation products (TBARS) and protein carbonyls in the liver and vitellogenin-like proteins (Vtg-LP) in the serum, but higher levels of glutathione in the liver in comparison with untreated frogs from the reference site.
2(0,0,0,2) Details
15207377 Jacobsen H, Ostergaard G, Lam HR, Poulsen ME, Frandsen H, Ladefoged O, Meyer O: Repeated dose 28-day oral toxicity study in Wistar rats with a mixture of five pesticides often found as residues in food: alphacypermethrin, bromopropylate, carbendazim, chlorpyrifos and mancozeb. Food Chem Toxicol. 2004 Aug;42(8):1269-77.

Plasma acetylcholinesterase was significantly decreased in the groups 2, 5 and 6 males.
1(0,0,0,1) Details