Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name methidathion
CAS

Reference List

PubMed Abstract RScore(About this table)
1375147 Szabo A, Nemcsok J, Asztalos B, Rakonczay Z, Kasa P, Hieu LH: The effect of pesticides on carp (Cyprinus carpio L). Ecotoxicol Environ Saf. 1992 Feb;23(1):39-45.

Tissue AChE activity was determined in response to specific inhibitors (ethopropazine, BW 284 C51) or pesticides (CuSO4, paraquat (PQ), methidathion (MD)).
38(0,1,1,8) Details
8825967 Flammarion P, Migeon B, Garric J: Joint effects of copper sulphate and methidathion on rainbow trout (Oncorhynchus mykiss) EROD and AChE activities. Bull Environ Contam Toxicol. 1996 Mar;56(3):440-5.
6(0,0,1,1) Details
9195193 Lang G, Kufcsak O, Szegletes T, Nemcsok J: Quantitative distributions of different cholinesterases and inhibition of acetylcholinesterase by metidathion and paraquat in alimentary canal of common carp. Gen Pharmacol. 1997 Jul;29(1):55-9.

4(0,0,0,4) Details
9404539 Hughes GM, Szegletes T, Nemcsok J: Study of the effects of brief exposure to an organophosphorous insecticide (methidathion) on blood characteristics of carp (Cyprinus carpio). Acta Biol Hung. 1997;48(2):157-66.

Blood samples taken during control, exposed and recovery periods were used to determine plasma acetylcholinesterase (AChE) activity, haematocrit value, mean cell volume, total plasma protein, and filtration time through Nucleopore filters containing pores of 8 microns. 2.
3(0,0,0,3) Details
18072155 Mohammad FK, Alias AS, Ahmed OA: Electrometric measurement of plasma, erythrocyte, and whole blood cholinesterase activities in healthy human volunteers. J Med Toxicol. 2007 Mar;3(1):25-30.

Following in vitro inhibition of pseudo cholinesterase by quinidine sulfate, true cholinesterase activity was estimated in the plasma of the subjects.
After in vitro addition of the organophosphate (chlorpyrifos and methidathion, 0.5 and 1 microM) and carbamate (carbaryl, 5 and 10 microM) insecticides to the reaction mixtures, inhibitions of blood cholinesterases were measured.
3(0,0,0,3) Details
15154489 Grafton-Cardwell EE, Ouyang Y, Striggow RA, Christiansen JA, Black CS: Role of esterase enzymes in monitoring for resistance of California red scale, Aonidiella aurantii (Homoptera: Diaspididae), to organophosphate and carbamate insecticides. J Econ Entomol. 2004 Apr;97(2):606-13.

Eighty-seven populations of California red scale, Aonidiella aurantii (Maskell), from the San Joaquin Valley of California were tested for insecticide resistance by using chlorpyrifos, methidathion, and/or carbaryl in a standard fruit-dip bioassay as well as for general esterase activity by using alpha-naphthyl acetate as a substrate in a colorimetric test.
The results of tests for activity and inhibition of acetylcholinesterase activity suggest that California red scale is using increased amounts of esterase enzymes, including acetylcholinesterase, to sequester organophosphate and carbamate insecticides, rather than modified acetylcholinesterase.
1(0,0,0,1) Details
3448863 Nemcsok J, Asztalos B, Vig E, Orban L: The effect of an organophosphorus pesticide on the enzymes of carp (Cyprinus carpio L.). Acta Biol Hung. 1987;38(1):77-85.


The effect of 1.5, 2.0 and 5.0 ppm methidation was studied on the ASAT, ALAT, LDH and AChE enzymes, as well as the blood sugar and adrenaline levels in carp. 2.
2(0,0,0,2) Details