| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | methomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 406567 | Schmid ER, Damboritz W, Markl P: [Radiometric determination of 11 pesticides in the nanogram and subnanongram ranges by means of cholinesterase inhibition]. Nahrung. 1977;21(4):311-7. This method for determining carbamates is based on the inhibiting action of these substances on acetylcholinesterase activity. The limit of detection for aldicarb, baygon, benomyl, bux, carbaryl, CIPC, matacil, phenmedipham and promecarb lies in the picogram range; that for barban and methomyl, in the nanogram range. |
1(0,0,0,1) | Details |
| 19934164 | Moser VC, McDaniel KL, Phillips PM, Lowit AB: Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats. Toxicol Sci. 2010 Mar;114(1):113-23. Epub 2009 Nov 24. N-Methyl insecticides are reversible inhibitors of central and peripheral acetylcholinesterase (ChE). To study potential age-related differences, we evaluated seven carbamates (carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur) in preweanling (17 days old or postnatal day [PND] 17) male rats. |
1(0,0,0,1) | Details |
| 12660363 | Dekundy A, Kaminski RM, Turski WA: Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice. Toxicol Sci. 2003 Apr;72(2):289-95. Coinjection of MEC (at both doses studied) and MK-801 completely prevented seizures produced by both acetylcholinesterase (AChE) inhibitors. |
1(0,0,0,1) | Details |
| 16718740 | Kristensen M, Huang J, Qiao CL, Jespersen JB: Variation of Musca domestica L. acetylcholinesterase in Danish housefly populations. Pest Manag Sci. 2006 Aug;62(8):738-45. Cluster analysis was performed and > 2000 houseflies were assigned to one of three phenotypes based on total acetylcholinesterase activity as well as inhibition by azamethiphos, methomyl or omethoate. |
170(2,2,3,5) | Details |
| 16461013 | Yi MQ, Liu HX, Shi XY, Liang P, Gao XW: Inhibitory effects of four insecticides on acetylcholinesterase of male and female Carassius auratus in vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2006 May;143(1):113-6. Epub 2006 Feb 3. The ratios of bimolecular rate constant (female/male) for AChE reacting with methomyl, thiodicarb, carbofuran and carbosulfan were 1.03, 2.44, 1.03 and 1.106, respectively. |
117(1,2,2,7) | Details |
| 11886776 | Tsagkarakou A, Pasteur N, Cuany A, Chevillon C, Navajas M: Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Insect Biochem Mol Biol. 2002 Apr;32(4):417-24. The kinetic characteristics of acetylcholinesterase, the target enzyme of organophosphates and carbamates, revealed that acetylcholinesterase in RLAB was less sensitive to inhibition by paraoxon and methomyl in comparison with SAMB. |
112(1,2,2,2) | Details |
| 10333576 | Rufingier C, Pasteur N, Lagnel J, Martin C, Navajas M: Mechanisms of insecticide resistance in the aphid Nasonovia ribisnigri (Mosley) (Homoptera: Aphididae) from France. Insect Biochem Mol Biol. 1999 Apr;29(4):385-91. Resistance to pirimicarb was shown to be mainly due to a decreased sensitivity of the target acetylcholinesterase; this modification conferred also, resistance to propoxur but not to methomyl and the two tested organophosphates (acephate and paraoxon). |
0(0,0,0,0) | Details |
| 2033303 | Ahmed YM: Kinetic study on inhibition of earthworm acetylcholinesterase by insecticides. J Egypt Soc Parasitol. 1991 Apr;21(1):283-92. The inhibition progress of the AChE by aldicarb was relatively rapid more than the other two tested inhibitors: carbofuran and methomyl. |
85(1,1,1,5) | Details |
| 18470629 | Essawy AE, Abdelmeguied NE, Radwan MA, Hamed SS, Hegazy AE: Neuropathological effect of molluscicides on the land snail, Eobania vermiculata. Cell Biol Toxicol. 2009 Jun;25(3):275-90. Epub 2008 May 10. However, methomyl exhibited more potency in reducing AChE activity than methiocarb. |
83(1,1,1,3) | Details |
| 571608 | Bracy OL, Doyle RS, Kennedy M, McNally SM, Weed JD, Thorne BM: Effects of methomyl and on behavior in the Sprague-Dawley rat. Pharmacol Biochem Behav. 1979 Jan;10(1):21-5. The group having the greatest reduction in AChE, the methomyl group, showed less evidence for habituation in an open-field test. |
82(1,1,1,2) | Details |
| 20092900 | Pereira JL, Hill CJ, Sibly RM, Bolshakov VN, Goncalves F, Heckmann LH, Callaghan A: Gene transcription in Daphnia magna: Effects of acute exposure to a insecticide and an acetanilide herbicide. Aquat Toxicol. 2010 Jan 6. Methomyl, a insecticide widely used in agriculture, inhibits acetylcholinesterase, a key enzyme in nerve transmission. |
81(1,1,1,1) | Details |
| 17092527 | Kaminski RM, Blaszczak P, Dekundy A, Parada-Turska J, Calderazzo L, Cavalheiro EA, Turski WA: Lithium-methomyl induced seizures in rats: a new model of status epilepticus?. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):122-7. Epub 2006 Oct 4. Behavioral, electroencephalographic (EEG) and neuropathological effects of methomyl, a insecticide reversibly inhibiting acetylcholinesterase activity, were studied in naive or lithium (24 h, 3 mEq/kg, s.c.) pretreated male Wistar rats. |
81(1,1,1,1) | Details |
| 19371631 | Bosgra S, van Eijkeren JC, van der Schans MJ, Langenberg JP, Slob W: Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):1-8. Epub 2009 Jan 20. |
64(0,2,2,4) | Details |
| 19608286 | Xuereb B, Lefevre E, Garric J, Geffard O: Acetylcholinesterase activity in Gammarus fossarum (Crustacea Amphipoda): linking AChE inhibition and behavioural alteration. Aquat Toxicol. 2009 Aug 31;94(2):114-22. Epub 2009 Jun 24. Relations between whole-body acetylcholinesterase (AChE) inhibition and changes in feeding and locomotor behaviours were investigated in adult male Gammarus fossarum during short-term exposure (96h) to the organophosphorous pesticide chlorpyrifos (CPE) and the pesticide methomyl (MT). |
37(0,1,1,7) | Details |
| 20103101 | He P, Davies J, Greenway G, Haswell SJ: Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Anal Chim Acta. 2010 Feb 5;659(1-2):9-14. Epub 2009 Dec 3. A bienzyme system containing co-immobilized acetylcholinesterase and oxidase was used for the evaluation of enzyme inhibition induced by malaoxon, eserine and methomyl analytes. |
33(0,1,1,3) | Details |
| 18476213 | Ahmad NW, Huang TS, Balabaskaran S, Lo KM, Das VG: Insecticidal Effects of Organotin (IV) Compounds on Plutella Xylostella (L.) Larvae. Met Based Drugs. 1994;1(1):1-17. The combination of (p-chlorophenyl) diphenyltin N,N-dimethyldithiocarbamate at LD (10) and LD (25) concentrations with sublethal concentrations of Malathion as well as of tricyclohexyltin methanesulphonate at the 0.01% (w/v) concentration with Malathion exerted strong synergistic effects (supplemental synergism) with toxicity index (T.I) values of 7.2, 19.8 and 10.1, respectively.Studies on the in vitro inhibition of acetylcholinesterase prepared from the DBM larvae showed that while most of the triorganotin Compounds tested were without effect on the enzyme, compounds containing the thiocarbamylacetate or the dithiocarbamylacetate moieties demonstrated appreciable levels of inhibition, being comparable in efficacy to commercial grades of Malathion and Methomyl. |
33(0,1,1,3) | Details |
| 2904862 | Price NR: Insecticide-insensitive acetylcholinesterase from a laboratory selected and a field strain of housefly (Musca domestica) (L.). Comp Biochem Physiol C. 1988;90(1):221-4. Acetylcholinesterase from the heads of a strain of houseflies selected for resistance to the insecticide methomyl, and from a methomyl-resistant field strain was found to be less sensitive to inhibition by methomyl than that from a susceptible strain. 2. |
32(0,1,1,2) | Details |
| 18366586 | Hoizey G, Canas F, Binet L, Kaltenbach ML, Jeunehomme G, Bernard MH, Lamiable D: Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning. J Forensic Sci. 2008 Mar;53(2):499-502. Thiodicarb is a nonsystemic insecticide whose acetylcholinesterase activity is related to its main methomyl degradation product. |
31(0,1,1,1) | Details |
| 11332849 | Byrne FJ, Toscano NC: An insensitive acetylcholinesterase confers resistance to methomyl in the beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae). J Econ Entomol. 2001 Apr;94(2):524-8. |
13(0,0,2,3) | Details |
| 18665458 | Li H, Jiang H, Gao X, Wang X, Qu W, Lin R, Chen J: Acute toxicity of the pesticide methomyl on the topmouth gudgeon (Pseudorasbora parva): mortality and effects on four biomarkers. Fish Physiol Biochem. 2008 Sep;34(3):209-16. Epub 2007 Aug 27. In this study, the acute toxicity of the pesticide methomyl on the topmouth gudgeon (Pseudorasbora parva) was evaluated using mortality and the activity of the enzymes acetylcholinesterase (AChE), glutathione S-transferases (GSTs), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) as endpoints. |
12(0,0,2,2) | Details |
| 1909249 | Rogers KR, Cao CJ, Valdes JJ, Eldefrawi AT, Eldefrawi ME: Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases. Fundam Appl Toxicol. 1991 May;16(4):810-20. The biosensor detected concentrations of the insecticides bendiocarb and methomyl and the OPs echothiophate and paraoxon in the nanomolar to micromolar range. |
7(0,0,0,7) | Details |
| 9682403 | Tsatsakis AM, Tutudaki MI, Tzatzarakis MN, Psaroudakis K, Dolapsakis GP, Michalodimitrakis MN: Pesticide deposition in hair: preliminary results of a model study of methomyl incorporation into rabbit hair. Vet Hum Toxicol. 1998 Aug;40(4):200-3. A total of 600 mg methomyl was administered by drinking water over 4 mo, and acetylcholinesterase activity in serum was monitored. |
7(0,0,1,2) | Details |
| 19825863 | Mansour SA, Mossa AT, Heikal TM: Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: in vitro studies. Toxicol Ind Health. 2009 Sep;25(8):557-63. The results showed that methomyl decreased acetylcholinesterase (AChE), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities and increased level of lipid peroxidation (LPO) as well as the percentage of haemolysis. |
6(0,0,1,1) | Details |
| 8134223 | Lifshitz M, Rotenberg M, Sofer S, Tamiri T, Shahak E, Almog S: poisoning and oxime treatment in children: a clinical and laboratory study. Pediatrics. 1994 Apr;93(4):652-5. The poisoning agents in all cases were positively identified as methomyl or aldicarb by gas chromatography-mass spectrometry. (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a (aldicarb or methomyl). |
6(0,0,1,1) | Details |
| 6616085 | Montz WE Jr, Scanlon PF, Kirkpatrick RL: Effects of field application of the anti-cholinesterase insecticide methomyl on brain acetylcholinesterase activities in wild Mus musculus. Bull Environ Contam Toxicol. 1983 Aug;31(2):158-63. |
6(0,0,1,1) | Details |
| 17192611 | Gunning RV: Inhibition of -insensitive acetylcholinesterase by piperonyl butoxide in Helicoverpa armigera. J Mol Neurosci. 2006;30(1-2):21-2. |
4(0,0,0,4) | Details |
| 9442915 | Kamal MA: Investigation of the effect of lannate on kinetic parameters of acetylcholinesterase: slightly concave mixed-type of inhibition system. Biochem Mol Biol Int. 1997 Dec;43(6):1183-93. |
3(0,0,0,3) | Details |
| 9397501 | Mohammad FK, Faris GA, al-Kassim NA: A modified electrometric method for measurement of erythrocyte acetylcholinesterase activity in sheep. Vet Hum Toxicol. 1997 Dec;39(6):337-9. The method was used to demonstrate in vitro inhibition of sheep EChE activity by the organophosphorus and insecticides dichlorvos and methomyl, respectively. |
2(0,0,0,2) | Details |
| 1637204 | Fossi MC, Leonzio C, Massi A, Lari L, Casini S: Serum esterase inhibition in birds: a nondestructive biomarker to assess organophosphorus and contamination. Arch Environ Contam Toxicol. 1992 Jul;23(1):99-104. With the aim of proposing a nondestructive biomarker for monitoring the toxicological risk to birds of exposure to the organophosphorus insecticide azamethiphos and the insecticide methomyl, laboratory studies were performed on serum "B" esterases in Japanese quail (Coturnix coturnix japonica). Serum BChE and brain acetylcholinesterase (AChE) were strongly inhibited after treatment with both insecticides. |
2(0,0,0,2) | Details |
| 19894225 | Khajehali J, Van Leeuwen T, Grispou M, Morou E, Alout H, Weill M, Tirry L, Vontas J, Tsagkarakou A: Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates. Pest Manag Sci. 2010 Feb;66(2):220-8. RESULTS: The resistance ratios of the OP strains varied from 9 to 43 for pirimiphos-methyl, from 78 to 586 for chlorpyrifos, from 8 to 333 for methomyl and from 137 to 4164 for dimethoate. |
2(0,0,0,2) | Details |
| 9890446 | Kamal MA, Al-jafari AA: Kinetic constants for the inhibition of camel retinal acetylcholinesterase by the insecticide lannate. J Biochem Mol Toxicol. 1999;13(1):41-6. |
2(0,0,0,2) | Details |
| 8980026 | Gunning RV, Moores GD, Devonshire AL: Insensitive Acetylcholinesterase and Resistance to Thiodicarb in Australian Helicoverpa armigera Hubner (Lepidoptera: Noctuidae). Pestic Biochem Physiol. 1996 May;55(1):21-8. Bioassays after selection in the laboratory indicated that the thiodicarb resistance factor was greater than 40-fold and was associated with cross resistance to methomyl. |
2(0,0,0,2) | Details |
| 9374595 | McCutchen BF, Hoover K, Preisler HK, Betana MD, Herrmann R, Robertson JL, Hammock BD: Interactions of recombinant and wild-type baculoviruses with classical insecticides and pyrethroid-resistant tobacco budworm (Lepidoptera: Noctuidae). J Econ Entomol. 1997 Oct;90(5):1170-80. A type II pyrethroid (cypermethrin, which modifies currents of channels) and a (methomyl, an inhibitor of acetylcholinesterase) were synergistic in combination with AcAaIT. A type II pyrethroid (cypermethrin, which modifies currents of channels) and a (methomyl, an inhibitor of acetylcholinesterase) were synergistic in combination with AcAaIT. |
1(0,0,0,1) | Details |
| 17824663 | Walz I, Schwack W: Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. J Agric Food Chem. 2007 Oct 3;55(20):8177-86. Epub 2007 Sep 8. This type of enzymatic oxidation is easier to perform and more efficient, as compared to or N-bromosuccinimide, used for acetylcholine esterase (AChE) assay in water analyses, but is insufficient for complex matrices such as plant sample extracts. Except for methomyl, no significant effects of CPO oxidation on the inhibition strength of insecticidal carbamates could be detected. |
1(0,0,0,1) | Details |
| 7991221 | Gupta RC, Goad JT, Kadel WL: Energy related metabolic alterations in diaphragm muscle resulting from acute methomyl toxicity. Neurotoxicology. 1994 Summer;15(2):321-30. In diaphragm, when the activity of acetylcholinesterase (AChE) was markedly depressed (82%), the levels of high-energy phosphates, (ATP) and (PCr) were also significantly lowered (27% and 54%, respectively). |
1(0,0,0,1) | Details |
| 19374387 | Mungkornasawakul P, Chaiyong S, Sastraruji T, Jatisatienr A, Jatisatienr C, Pyne SG, Ung AT, Korth J, Lie W: Alkaloids from the Roots of Stemona aphylla. J Nat Prod. 2009 Apr 17. The results of their acetylcholinesterase (AChE) inhibitory activities showed that the crude extract had higher activity than that of 4. The insecticidal properties of the crude extract and 4, using a topical application, showed that 4 had an activity similar to the positive control, methomyl, whereas the crude extract had much lower activity. |
1(0,0,0,1) | Details |
| 11218047 | Dekundy A, Blaszczak P, Kaminski R, Turski WA: On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Arch Toxicol. 2001 Jan;74(11):702-8. Both organophosphate (OP) and pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (AChE) and subsequent excess of |
1(0,0,0,1) | Details |
| 17096373 | Topacoglu H, Unverir P, Erbil B, Sarikaya S: An unusual cause of atrial fibrillation: exposure to insecticides. Am J Ind Med. 2007 Jan;50(1):48-9. CASE: Twenty-six-year-old male, complaining of nausea and vomiting, presented to the emergency department with a history of methomyl dust exposure. Patient's acetylcholinesterase (ACE) level was 3,319 IU/L in presentation and pralidoxim use was seen unnecessary for the treatment. |
1(0,0,0,1) | Details |