| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | methomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9022648 | Lifshitz M, Shahak E, Bolotin A, Sofer S: poisoning in early childhood and in adults. J Toxicol Clin Toxicol. 1997;35(1):25-7. The ingested poisons in all cases were positively identified as methomyl or aldicarb by gas chromatography-mass spectrometry. RESULTS: Symptoms of intoxication in children were compared to those in adults with similar depression of the serum cholinesterase. |
1(0,0,0,1) | Details |
| 11218047 | Dekundy A, Blaszczak P, Kaminski R, Turski WA: On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Arch Toxicol. 2001 Jan;74(11):702-8. |
1(0,0,0,1) | Details |
| 15749358 | Moriya F, Hashimoto Y: A fatal poisoning caused by methomyl and . Forensic Sci Int. 2005 May 10;149(2-3):167-70. The serum cholinesterase activities were 47-90 IU (normal range for male: 200-440 IU). |
1(0,0,0,1) | Details |
| 8134223 | Lifshitz M, Rotenberg M, Sofer S, Tamiri T, Shahak E, Almog S: poisoning and oxime treatment in children: a clinical and laboratory study. Pediatrics. 1994 Apr;93(4):652-5. OBJECTIVE: (1) Retrospective evaluation of the clinical course of poisoning and the effect of oxime therapy in children. (2) In vitro study of the effect of oximes on the reactivation of carbamylated cholinesterase. The poisoning agents in all cases were positively identified as methomyl or aldicarb by gas chromatography-mass spectrometry. (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a (aldicarb or methomyl). |
1(0,0,0,1) | Details |
| 18366586 | Hoizey G, Canas F, Binet L, Kaltenbach ML, Jeunehomme G, Bernard MH, Lamiable D: Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning. J Forensic Sci. 2008 Mar;53(2):499-502. The anticholinesterase capacity of blood, urine, and gastric content collected at autopsy was 83%, 82%, and 32%, respectively (normal value: 0%). |
1(0,0,0,1) | Details |
| 19079663 | Khan DA, Bhatti MM, Khan FA, Naqvi ST, Karam A: Adverse effects of pesticides residues on biochemical markers in pakistani tobacco farmers. Int J Clin Exp Med. 2008;1(3):274-82. Epub 2008 Jul 15. Plasma butyrylcholinesterase (BChE) was analyzed by Ellman's method. The tobacco farmers had multiple pesticides residues above ADI in their blood consisting of 35 (63%) methomyl; 31 (56%) thiodicarb; 34 (62%) cypermethrin; 27 (49%) Imidacloprid; 18 (32%) Methamidophos and 15 (27%) endosulfan. |
1(0,0,0,1) | Details |
| 406567 | Schmid ER, Damboritz W, Markl P: [Radiometric determination of 11 pesticides in the nanogram and subnanongram ranges by means of cholinesterase inhibition]. Nahrung. 1977;21(4):311-7. The limit of detection for aldicarb, baygon, benomyl, bux, carbaryl, CIPC, matacil, phenmedipham and promecarb lies in the picogram range; that for barban and methomyl, in the nanogram range. |
1(0,0,0,1) | Details |
| 17972302 | Kristensen M, Jespersen JB: Susceptibility to thiamethoxam of Musca domestica from Danish livestock farms. Pest Manag Sci. 2008 Feb;64(2):126-32. BACKGROUND: Neonicotinoid baits are currently replacing anticholinesterase baits for control of adult houseflies (Musca domestica L.). RESULTS: In feeding bioassay with a susceptible strain, thiamethoxam LC (50) at 72 h was 1.7 microg thiamethoxam g (-1) sugar, making it 19-fold, 11-fold and threefold more toxic to houseflies than azamethiphos, methomyl and spinosad respectively. |
1(0,0,0,1) | Details |
| 9397501 | Mohammad FK, Faris GA, al-Kassim NA: A modified electrometric method for measurement of erythrocyte acetylcholinesterase activity in sheep. Vet Hum Toxicol. 1997 Dec;39(6):337-9. The method was used to demonstrate in vitro inhibition of sheep EChE activity by the organophosphorus and insecticides dichlorvos and methomyl, respectively. |
0(0,0,0,0) | Details |
| 10220078 | Lifshitz M, Shahak E, Sofer S: and organophosphate poisoning in young children. Pediatr Emerg Care. 1999 Apr;15(2):102-3. The agents were identified as methomyl or aldicarb, and the organophosphate as parathion, fenthion, malathion, and diazinon. |
0(0,0,0,0) | Details |
| 9397503 | Shlosberg A, Bellaiche M, Hanji V, Ershov E: New treatment regimens in organophosphate (diazinon) and (methomyl) insecticide-induced toxicosis in fowl. Vet Hum Toxicol. 1997 Dec;39(6):347-50. |
0(0,0,0,0) | Details |
| 17197007 | Padilla S, Marshall RS, Hunter DL, Lowit A: Time course of cholinesterase inhibition in adult rats treated acutely with carbaryl, carbofuran, formetanate, methomyl, methiocarb, oxamyl or propoxur. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):202-9. Epub 2006 Nov 15. |
82(1,1,1,2) | Details |
| 17159234 | Lassiter TL, Brimijoin S: A method to determine precise benchmark doses for anticholinesterases. Toxicol Sci. 2007 Mar;96(1):154-61. Epub 2006 Dec 11. In determining benchmark doses for risk assessment and regulation of anticholinesterase pesticides like formetanate, oxamyl, and methomyl, one needs to quantitate low levels of cholinesterase inhibition. |
34(0,1,1,4) | Details |
| 1349226 | Saiyed HN, Sadhu HG, Bhatnagar VK, Dewan A, Venkaiah K, Kashyap SK: Cardiac toxicity following short-term exposure to methomyl in spraymen and rabbits. Hum Exp Toxicol. 1992 Mar;11(2):93-7. The study results indicate that these changes are probably directly related to methomyl rather than its toxicity through cholinesterase inhibition. |
32(0,1,1,2) | Details |
| 8612054 | Tsatsakis AM, Tsakalof AK, Siatitsas Y, Michalodimitrakis EN: Acute poisoning with pesticides: the Cretan experience. Sci Justice. 1996 Jan-Mar;36(1):35-9. Five cases are reported, involving the fatal ingestion of methomyl (Lannate), a cholinesterase-inhibiting insecticide. |
32(0,1,1,2) | Details |
| 159154 | Morse DL, Baker EL Jr, Kimbrough RD, Wisseman CL 3rd: Propanil-chloracne and methomyl toxicity in workers of a pesticide manufacturing plant. Clin Toxicol. 1979;15(1):13-21. Commonest causes of hospitalization were intoxication by the pesticide methomyl [1-(methylthio) ethylideneamino methyl a reversible cholinesterase inhibitor, and methemoglobinemia following exposure to 3,4-dichloroaniline. |
31(0,1,1,1) | Details |
| 10376354 | Lohitnavy O, Sinhaseni P: Increase in lactate dehydrogenase isoenzyme-4 and splenocyte toxicity in methomyl-treated rats. Arh Hig Rada Toksikol. 1998 Sep;49(3):231-8. The results suggest that the splenotoxic effect of methomyl is more likely directly related to oxidative cell injury than to cholinesterase inhibition. |
31(0,1,1,1) | Details |
| 6154073 | Riskallah MR: Reduced sensitivity of cholinesterase as a factor of resistance in leptophos selected strain in the Egyptian cotton leafworm. J Environ Sci Health B. 1980;15(2):181-92. Resistant larvae, which remained susceptible to the methomyl possessed cholinesterase of nearly normal sensitivity to this compound. |
10(0,0,1,5) | Details |
| 2729280 | Ames RG, Brown SK, Mengle DC, Kahn E, Stratton JW, Jackson RJ: Cholinesterase activity depression among California agricultural pesticide applicators. Am J Ind Med. 1989;15(2):143-50. Pesticides most frequently associated with cholinesterase depressions exceeding California threshold values included mevinphos (Phosdrin), oxydemeton methyl (Metasystox-R), methomyl (Lannate), and acephate (Orthene); these pesticides included organophosphates in toxicity categories I and II and one in toxicity category I. |
9(0,0,1,4) | Details |
| 20224101 | Villar D, Balvin D, Giraldo C, Motas M, Olivera M: Plasma and brain cholinesterase in methomyl-intoxicated free-ranging pigeons (Columba livia f. domestica). J Vet Diagn Invest. 2010 Mar;22(2):313-5. |
7(0,0,1,2) | Details |
| 11800311 | Ruangyuttikarn W, Phakdeewut T, Sainumtan W, Sribanditmongkol P: Children's plasma cholinesterase activity and fatal methomyl poisoning. J Med Assoc Thai. 2001 Sep;84(9):1344-50. |
7(0,0,1,2) | Details |
| 8645116 | Sinhaseni P, Foongvidya S, Tayaputch N: Exposure evaluation is a crucial step for quantitative risk assessment of methomyl. Arh Hig Rada Toksikol. 1995 Sep;46(3):301-6. Methomyl, methyl N-[[(methylamino) carbonyl] oxy] ethanimidothioate is a insecticide with anticholinesterase activity. |
6(0,0,1,1) | Details |
| 6616085 | Montz WE Jr, Scanlon PF, Kirkpatrick RL: Effects of field application of the anti-cholinesterase insecticide methomyl on brain acetylcholinesterase activities in wild Mus musculus. Bull Environ Contam Toxicol. 1983 Aug;31(2):158-63. |
6(0,0,1,1) | Details |
| 15929901 | Roldan-Tapi L, Leyva A, Laynez F, Santed FS: Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoning. Environ Health Perspect. 2005 Jun;113(6):762-6. |
6(0,0,0,6) | Details |
| 15767733 | Makrides C, Koukouvas M, Achillews G, Tsikkos S, Vounou E, Symeonides M, Christodoulides P, Ioannides M: Methomyl-induced severe acute pancreatitis: possible etiological association. JOP. 2005 Mar 10;6(2):166-71. They share the capacity to inhibit cholinesterase enzymes with organophosphates and therefore share similar symptomatology during acute and chronic exposures. |
4(0,0,0,4) | Details |
| 12660363 | Dekundy A, Kaminski RM, Turski WA: Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice. Toxicol Sci. 2003 Apr;72(2):289-95. |
4(0,0,0,4) | Details |
| 17504769 | McDaniel KL, Padilla S, Marshall RS, Phillips PM, Podhorniak L, Qian Y, Moser VC: Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat. Toxicol Sci. 2007 Aug;98(2):552-60. Epub 2007 May 15. The chemicals tested were carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur. |
3(0,0,0,3) | Details |
| 895649 | Simpson GR, Bermingham S: Poisoning by pesticides. Med J Aust. 1977 Jul 30;2(5):148-9. Because of this, separate tests for plasma and red blood cell levels of cholinesterase should be conducted as soon as possible after exposure in order to obtain meaningful results. The substitution of a liquid pesticide formulation for the original powder formulation has reduced the operator inhalation hazard in the case of methomyl. |
2(0,0,0,2) | Details |
| 16718740 | Kristensen M, Huang J, Qiao CL, Jespersen JB: Variation of Musca domestica L. acetylcholinesterase in Danish housefly populations. Pest Manag Sci. 2006 Aug;62(8):738-45. Anti-cholinesterase resistance is in many cases caused by modified acetylcholinesterase (MACE). A comparison was made of toxicological data and AChE activity gathered from 21 field populations and nine laboratory strains of houseflies, Musca domestica L., to elucidate the best way of generating data to provide advice for management strategies and gathering information for resistance risk assessment on the organophosphates azamethiphos and dimethoate and the methomyl, which have been the primary insecticides used against adult houseflies in Denmark. |
2(0,0,0,2) | Details |
| 10582355 | Moriya F, Hashimoto Y: Comparative studies on tissue distributions of organophosphorus, and organochlorine pesticides in decedents intoxicated with these chemicals. J Forensic Sci. 1999 Nov;44(6):1131-5. This paper describes the tissue distributions of dichlorvos, an organophosphate, chlorpyrifos-methyl, an organophosphorothioate, methomyl, a and endrin, an organochlorine, in three individuals (Cases 1-3) who died after ingesting insecticidal preparations containing these chemicals. The serum cholinesterase activity was 3 IU/L/37 degrees C. |
2(0,0,0,2) | Details |
| 20040949 | Patil JA, Patil AJ, Sontakke AV, Govindwar SP: Effect of methomyl on hepatic mixed function oxidases in rats. Indian J Pharmacol. 2008 Aug;40(4):158-63. The activities of drug metabolizing enzymes, hemoglobin content, liver function enzymes, and serum cholinesterase activity were assayed by using standard methods. |
2(0,0,0,2) | Details |
| 3591648 | Ta'naka I, Igisu H, Haratake J, Cho S, Mori K, Fujishiro K, Inoue N, Horie A, Akiyama T: Cumulative toxicity potential of methomyl aerosol by repeated inhalation. Am Ind Hyg Assoc J. 1987 Apr;48(4):330-4. After the repeated exposures, plasma and red cell cholinesterase activities, and lipid concentrations of the rat lungs were measured and histopathological examinations were performed. |
1(0,0,0,1) | Details |
| 1637204 | Fossi MC, Leonzio C, Massi A, Lari L, Casini S: Serum esterase inhibition in birds: a nondestructive biomarker to assess organophosphorus and contamination. Arch Environ Contam Toxicol. 1992 Jul;23(1):99-104. With the aim of proposing a nondestructive biomarker for monitoring the toxicological risk to birds of exposure to the organophosphorus insecticide azamethiphos and the insecticide methomyl, laboratory studies were performed on serum "B" esterases in Japanese quail (Coturnix coturnix japonica). In the first treatment, serum butyrylcholinesterase (BChE) and carboxylesterase (CbE) were drastically inhibited in the azamethiphos-treated group, 24 h after the dose. |
1(0,0,0,1) | Details |
| 16173456 | Kudo K, Hida Y, Zaitsu A, Inoue H, Tsuji A, Ishida T, Ikeda N: A case of poisoning in a man who drank a nutrition supplement containing methomyl, a pesticide. Fukuoka Igaku Zasshi. 2005 Jul;96(7):305-10. As myosis and decrease of serum choline esterase activity were observed on admission examination, poisoning was suspected and toxicological analyses were carried out on the heeltap of the drink. |
1(0,0,0,1) | Details |
| 14694629 | Xiao C, Niu Y, He F: [Stimulation single fiber electromyography in rats with myasthenia induced by organophosphorus insecticides and their mixtures poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002 Apr;20(2):125-7. OBJECTIVE: To study the neuromuscular function and its relation with the occurrence of myasthenia in rats poisoned by dimethoate (D), phoxim (P), methomyl (M), M + D and M + P respectively. The whole blood cholinesterase (ChE) activity was measured 1 h before and after poisoning. |
1(0,0,0,1) | Details |