| Name | androgen binding protein |
|---|---|
| Synonyms | ABP; SBP; Androgen binding protein; SHBG; Sex hormone binding globulin; Sex hormone binding globulin precursor; Sex steroid binding protein; TeBG… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18401575 | Vaithinathan S, Saradha B, Mathur PP: Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study. Arch Toxicol. 2008 Nov;82(11):833-9. Epub 2008 Apr 10. To get more insight into the mechanism (s) of gonadal toxicity provoked by methoxychlor, we investigated whether treatment with methoxychlor at low observed adverse effect level (LOAEL) would alter the activities of steroidogenic enzymes such as Delta (5) 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and Delta (5) 17beta-hydroxysteroid dehydrogenase (17beta-HSD), the expression levels of steroidogenic acute regulatory (StAR) protein and androgen binding protein (ABP) in the testis of adult male rats. |
31(0,1,1,1) | Details |
| 9171990 | Danzo BJ: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect. 1997 Mar;105(3):294-301. To determine whether xenobiotics (present at a concentration of 100 microM) exert their action through steroid-mediated pathways, we examined their ability to inhibit the binding of [3H] physiological ligands (present at a concentration of 7 nM) to the androgen and estrogen receptors, rat androgen-binding protein (ABP), and human sex hormone-binding globulin (hSHBG). Methoxychlor, o,p'-DDT1, pentachlorophenol, and nonylphenol significantly reduced [3H] 17 beta- binding to the estrogen receptor by 10, 60, 20, and 75%, respectively. |
1(0,0,0,1) | Details |
| 2925022 | Gray LE Jr, Ostby J, Ferrell J, Rehnberg G, Linder R, Cooper R, Goldman J, Slott V, Laskey J: A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam Appl Toxicol. 1989 Jan;12(1):92-108. and androgen-binding protein were measured in the caput epididymis, and sperm motility and morphology were evaluated from a caudal sample. |
1(0,0,0,1) | Details |