| Name | constitutive androstane receptor |
|---|---|
| Synonyms | CAR; CAR beta; CAR 1; CAR1; CARb; CARbeta; Constitutive activator of retinoid response; Constitutive active response… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11353743 | Blizard D, Sueyoshi T, Negishi M, Dehal SS, Kupfer D: Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. Drug Metab Dispos. 2001 Jun;29(6):781-5. |
162(2,2,2,2) | Details |
| 18973326 | Repo S, Jyrkkarinne J, Pulkkinen JT, Laatikainen R, Honkakoski P, Johnson MS: Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis. J Med Chem. 2008 Nov 27;51(22):7119-31. |
2(0,0,0,2) | Details |
| 12948398 | Makinen J, Reinisalo M, Niemi K, Viitala P, Jyrkkarinne J, Chung H, Pelkonen O, Honkakoski P: Dual action of oestrogens on the mouse constitutive androstane receptor. . Biochem J. 2003 Dec 1;376(Pt 2):465-72. This novel dual action is not limited to oestrogens, but is shared by some xenobiotic CYP2B inducers such as and methoxychlor. |
2(0,0,0,2) | Details |
| 16054614 | Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? . Chem Biol Interact. 2005 Aug 15;155(3):111-28. The pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands. Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. |
1(0,0,0,1) | Details |
| 15466163 | Yueh MF, Kawahara M, Raucy J: High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. Drug Metab Dispos. 2005 Jan;33(1):38-48. Epub 2004 Oct 1. Treatment of stable transformants, namely DPX-2, with various concentrations of inducers including rifampicin, mifepristone, troglitazone, methoxychlor, and kava produced dose-dependent increases in luciferase expression (between 2- and 40-fold above -treated cells). Constitutive androstane receptor-mediated regulation of CYP3A4 protein was addressed by measuring catalytic activity in a separate cell line over-expressing this receptor. |
1(0,0,0,1) | Details |