| Name | CYP2B6 |
|---|---|
| Synonyms | CPB 6; CPB6; CYP2B; CYP2B protein; CYP2B6; CYPIIB 6; CYPIIB6; Cytochrome P450 2B6… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10101147 | Stresser DM, Kupfer D: Monospecific antipeptide antibody to cytochrome P-450 2B6. Drug Metab Dispos. 1999 Apr;27(4):517-25. The utility of this antibody for determining human liver microsomal CYP2B6 contribution to the ortho-hydroxylation of methoxychlor was demonstrated. |
88(1,1,1,8) | Details |
| 11353743 | Blizard D, Sueyoshi T, Negishi M, Dehal SS, Kupfer D: Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. Drug Metab Dispos. 2001 Jun;29(6):781-5. Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the constitutive androstane receptor (CAR) system and induce CYP2B6 (J Biol Chem 1999;274:6043-6046), suggesting a mechanism for methoxychlor-mediated cytochrome P450 (P450) 2B induction. |
81(1,1,1,1) | Details |
| 9241656 | Ekins S, VandenBranden M, Ring BJ, Wrighton SA: Examination of purported probes of human CYP2B6. . Pharmacogenetics. 1997 Jun;7(3):165-79. Methoxychlor and S-mephenytoin inhibited expressed CYP2B6 but not CYP1A2 mediated 7-EFC O-deethylation. |
6(0,0,0,6) | Details |
| 9733665 | Stresser DM, Kupfer D: Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an Drug Metab Dispos. 1998 Sep;26(9):868-74. CYP2B6 and CYP2C9 were much less active. |
2(0,0,0,2) | Details |
| 12167570 | Hu Y, Kupfer D: Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel metabolite. Drug Metab Dispos. 2002 Sep;30(9):1035-42. CYP2B6 appeared unique, catalyzing effectively both O-demethylation and ortho-hydroxylation. |
1(0,0,0,1) | Details |
| 9047321 | Stresser DM, Kupfer D: Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of and mono-O-demethylated methoxychlor. Biochemistry. 1997 Feb 25;36(8):2203-10. |
0(0,0,0,0) | Details |
| 7895613 | Dehal SS, Kupfer D: Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Drug Metab Dispos. 1994 Nov-Dec;22(6):937-46. Human CYP2B6 exhibits ring-hydroxylation, indicating that this reaction is catalyzed by several CYP2B isozymes. |
1(0,0,0,1) | Details |